Ruthenium-based complex nanocarriers for cancer therapy

被引：77

作者：

Mangiapia, Gaetano ^{[1
]}

D'Errico, Gerardino ^{[1
]}

Simeone, Luca ^{[1
]}

Irace, Carlo ^{[2
]}

Radulescu, Aurel ^{[3
]}

Di Pascale, Antonio ^{[2
]}

Colonna, Alfredo ^{[2
]}

Montesarchio, Daniela ^{[1
]}

Paduano, Luigi ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Sci Chim, I-80126 Naples, Italy

[2] Univ Naples Federico II, Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy

[3] Julich Ctr Neutron Sci, D-85747 Garching, Germany

来源：

BIOMATERIALS | 2012年 / 33卷 / 14期

关键词：

Ruthenium-based complexes; Antineoplastic agents; Nanoaggregates; Anti-proliferative activity; ANGLE NEUTRON-SCATTERING; NAMI-A; GADOLINIUM COMPLEXES; CHEMICAL-STABILITY; CONTRAST AGENTS; TERNARY-SYSTEM; PLATINUM DRUGS; PHASE-I; COEFFICIENTS; CHOLESTEROL;

D O I：

10.1016/j.biomaterials.2012.01.057

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A new organometallic ruthenium complex, named AziRu, along with three amphiphilic nucleoside-based ruthenium complexes, ToThyRu, HoThyRu and DoHuRu, incorporating AziRu in their skeleton, have been synthesized, stabilized in POPC phospholipid formulations and studied for their antineoplastic activity. Self-aggregation behavior of these complexes was investigated, showing that the three synthesized AziRu derivatives able to form liposomes and, under specific conditions, elongated micelles. The formulations prepared in POPC proved to be stable for months and showed high in vitro antiproliferative activity. The here described results open new scenarios in the design of innovative transition metal-based supramolecular systems for anticancer drugs vectorization. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：3770 / 3782

页数：13

共 50 条

[1]

Adjei AA, 2003, CANCER BIOL THER, V2, pS5

[2] Stiffening Effect of Cholesterol on Disordered Lipid Phases: A Combined Neutron Spin Echo plus Dynamic Light Scattering Analysis of the Bending Elasticity of Large Unilamellar Vesicles [J].

Arriaga, Laura R. ;

Lopez-Montero, Ivan ;

Monroy, Francisco ;

Orts-Gil, Guillermo ;

Farago, Bela ;

Hellweg, Thomas .

BIOPHYSICAL JOURNAL, 2009, 96 (09) :3629-3637

[3] Nucleoside-based lipids at work: From supramolecular assemblies to biological applications [J].

Barthelemy, Philippe .

COMPTES RENDUS CHIMIE, 2009, 12 (1-2) :171-179

[4] Treatment of residual metastases with Na[trans-RuCl4(DMSO)Im] and ruthenium uptake by tumor cells [J].

Bergamo, A ;

Cocchietto, M ;

Capozzi, I ;

Mestroni, G ;

Alessio, E ;

Sava, G .

ANTI-CANCER DRUGS, 1996, 7 (06) :697-702

[5]

Berne B. J., 1975, DYNAMIC LIGHT SCATTE

[6] Amphiphilic self-assemblies decorated by nucleobases [J].

Berti, Debora ;

Bombelli, Francesca Baldelli ;

Fortini, Martina ;

Baglioni, Piero .

JOURNAL OF PHYSICAL CHEMISTRY B, 2007, 111 (40) :11734-11744

[7]

Boulikas T, 2003, ONCOL REP, V10, P1663

[8] A kinetic study of the chemical stability of the antimetastatic ruthenium complex NAMI-A [J].

Bouma, M ;

Nuijen, B ;

Jansen, MT ;

Sava, G ;

Flaibani, A ;

Bult, A ;

Beijnen, JH .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 248 (1-2) :239-246

[9]

Campbell RB, 2002, CANCER RES, V62, P6831

[10] DEFINITION OF PH SCALES, STANDARD REFERENCE VALUES, MEASUREMENT OF PH AND RELATED TERMINOLOGY [J].

COVINGTON, AK ;

BATES, RG ;

DURST, RA .

PURE AND APPLIED CHEMISTRY, 1983, 55 (09) :1467-1476

← 1 2 3 4 5 →