Selenium and the control of thyroid hormone metabolism

被引:111
作者
Köhrle, J [1 ]
机构
[1] Humboldt Univ, Charite Univ Med Berlin, Charite EnForCe, Inst expt Endokrinol & Endokrinol Forsch, D-10098 Berlin, Germany
关键词
D O I
10.1089/thy.2005.15.841
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thyroid hormone synthesis, metabolism and action require adequate availability of the essential trace elements iodine and selenium, which affect homeostasis of thyroid hormone-dependent metabolic pathways. The three selenocysteine-containing iodothyronine deiodinases constitute a novel gene family. Selenium is retained and deiodinase expression is maintained at almost normal levels in the thyroid gland, the brain and several other endocrine tissues during selenium deficiency, thus guaranteeing adequate local and systemic levels of the active thyroid hormone T-3. Due to their low tissue concentrations and their mRNA SECTS elements deiodinases rank high in the cellular and tissue-specific hierarchy of selenium distribution among various selenoproteins. While systemic selenium status and expression of abundant selenoproteins (glutathione peroxidase or seleno-protein P) is already impaired in patients with cancer, disturbed gastrointestinal resorption, unbalanced nutrition or patients requiring intensive care treatment, selenium-dependent deiodinase function might still be adequate. However, disease-associated alterations in proinflammatory cytokines, growth factors, hormones and pharmaceuticals modulate deiodinase isoenzyme expression independent from altered selenium status and might thus pretend causal relationships between systemic selenium status and altered thyroid hormone metabolism. Limited or inadequate supply of both trace elements, iodine and selenium, leads to complex re-arrangements of thyroid hormone metabolism enabling adaptation to unfavorable conditions.
引用
收藏
页码:841 / 853
页数:13
相关论文
共 154 条
[31]  
CAMMACK PM, 1995, J NUTR, V125, P302
[32]   Effects of selenium and iodine deficiency on thyroid hormone concentrations in the central nervous system of the rat [J].
CamposBarros, A ;
Meinhold, H ;
Walzog, B ;
Behne, D .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1997, 136 (03) :316-323
[33]   Selenium and thyroid function in infants, children and adolescents [J].
Chanoine, JP .
BIOFACTORS, 2003, 19 (3-4) :137-143
[34]   SELENIUM DEFICIENCY AND TYPE-II 5'-DEIODINASE REGULATION IN THE EUTHYROID AND HYPOTHYROID RAT - EVIDENCE OF A DIRECT EFFECT OF THYROXINE [J].
CHANOINE, JP ;
SAFRAN, M ;
FARWELL, AP ;
TRANTER, P ;
EKENBARGER, DM ;
DUBORD, S ;
ALEX, S ;
ARTHUR, JR ;
BECKETT, GJ ;
BRAVERMAN, LE ;
LEONARD, JL .
ENDOCRINOLOGY, 1992, 131 (01) :479-484
[35]   Selenium decreases thyroglobulin concentrations but does not affect the increased thyroxine-to-triiodothyronine ratio in children with congenital hypothyroidism [J].
Chanoine, JP ;
Nève, J ;
Wu, S ;
Vanderpas, J ;
Bourdoux, P .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (03) :1160-1163
[36]   PLACENTAL 5-DEIODINASE ACTIVITY AND FETAL THYROID-HORMONE ECONOMY ARE UNAFFECTED BY SELENIUM DEFICIENCY IN THE RAT [J].
CHANOINE, JP ;
ALEX, S ;
STONE, S ;
FANG, SL ;
VERONIKIS, I ;
LEONARD, JL ;
BRAVERMAN, LE .
PEDIATRIC RESEARCH, 1993, 34 (03) :288-292
[37]   TISSUE-SPECIFICITY OF SELENOPROTEIN GENE-EXPRESSION IN RATS [J].
CHRISTENSEN, MJ ;
CAMMACK, PM ;
WRAY, CD .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 1995, 6 (07) :367-372
[38]   Effects of iodine repletion on thyroid morphology in iodine and or selenium deficient rat term fetuses, pups and mothers [J].
Colzani, RM ;
Alex, S ;
Fang, SL ;
Stone, S ;
Braverman, LE .
BIOCHIMIE, 1999, 81 (05) :485-491
[39]  
Combs G F Jr, 1997, Biomed Environ Sci, V10, P356
[40]   Chemopreventive agents: Selenium [J].
Combs, GF ;
Gray, WP .
PHARMACOLOGY & THERAPEUTICS, 1998, 79 (03) :179-192