Selenium and the control of thyroid hormone metabolism

被引:110
作者
Köhrle, J [1 ]
机构
[1] Humboldt Univ, Charite Univ Med Berlin, Charite EnForCe, Inst expt Endokrinol & Endokrinol Forsch, D-10098 Berlin, Germany
关键词
D O I
10.1089/thy.2005.15.841
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thyroid hormone synthesis, metabolism and action require adequate availability of the essential trace elements iodine and selenium, which affect homeostasis of thyroid hormone-dependent metabolic pathways. The three selenocysteine-containing iodothyronine deiodinases constitute a novel gene family. Selenium is retained and deiodinase expression is maintained at almost normal levels in the thyroid gland, the brain and several other endocrine tissues during selenium deficiency, thus guaranteeing adequate local and systemic levels of the active thyroid hormone T-3. Due to their low tissue concentrations and their mRNA SECTS elements deiodinases rank high in the cellular and tissue-specific hierarchy of selenium distribution among various selenoproteins. While systemic selenium status and expression of abundant selenoproteins (glutathione peroxidase or seleno-protein P) is already impaired in patients with cancer, disturbed gastrointestinal resorption, unbalanced nutrition or patients requiring intensive care treatment, selenium-dependent deiodinase function might still be adequate. However, disease-associated alterations in proinflammatory cytokines, growth factors, hormones and pharmaceuticals modulate deiodinase isoenzyme expression independent from altered selenium status and might thus pretend causal relationships between systemic selenium status and altered thyroid hormone metabolism. Limited or inadequate supply of both trace elements, iodine and selenium, leads to complex re-arrangements of thyroid hormone metabolism enabling adaptation to unfavorable conditions.
引用
收藏
页码:841 / 853
页数:13
相关论文
共 154 条
  • [21] SELENOCYSTEINE INSERTION OR TERMINATION - FACTORS AFFECTING UGA CODON FATE AND COMPLEMENTARY ANTICODON-CODON MUTATIONS
    BERRY, MJ
    HARNEY, JW
    OHAMA, T
    HATFIELD, DL
    [J]. NUCLEIC ACIDS RESEARCH, 1994, 22 (18) : 3753 - 3759
  • [22] TYPE-I IODOTHYRONINE DEIODINASE IS A SELENOCYSTEINE-CONTAINING ENZYME
    BERRY, MJ
    BANU, L
    LARSEN, PR
    [J]. NATURE, 1991, 349 (6308) : 438 - 440
  • [23] Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases
    Bianco, AC
    Salvatore, D
    Gereben, B
    Berry, MJ
    Larsen, PR
    [J]. ENDOCRINE REVIEWS, 2002, 23 (01) : 38 - 89
  • [24] SELENOPROTEIN SYNTHESIS - AN EXPANSION OF THE GENETIC-CODE
    BOCK, A
    FORCHHAMMER, K
    HEIDER, J
    BARON, C
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1991, 16 (12) : 463 - 467
  • [25] EARLY ADAPTATION OF THYROTROPIN AND THYROGLOBULIN SECRETION TO EXPERIMENTALLY DECREASED IODINE SUPPLY IN MAN
    BRABANT, G
    BERGMANN, P
    KIRSCH, CM
    KOHRLE, J
    HESCH, RD
    VONZURMUHLEN, A
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1992, 41 (10): : 1093 - 1096
  • [26] Bratter P, 1996, J TRACE ELEM MED BIO, V10, P163
  • [27] The role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase
    Buettner, C
    Harney, JW
    Larsen, PR
    [J]. ENDOCRINOLOGY, 2000, 141 (12) : 4606 - 4612
  • [28] The 3′-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element
    Buettner, C
    Harney, JW
    Larsen, PR
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (50) : 33374 - 33378
  • [29] EFFECTS OF SELENIUM SUPPLEMENTATION ON THYROID-HORMONE METABOLISM IN PHENYLKETONURIA SUBJECTS ON A PHENYLALANINE RESTRICTED DIET
    CALOMME, M
    VANDERPAS, J
    FRANCOIS, B
    VANCAILLIEBERTRAND, M
    VANOVERVELT, N
    VANHOOREBEKE, C
    VANDENBERGHE, D
    [J]. BIOLOGICAL TRACE ELEMENT RESEARCH, 1995, 47 (1-3) : 349 - 353
  • [30] Thyroid function parameters during a selenium repletion depletion study in phenylketonuric subjects
    Calomme, MR
    Vanderpas, JB
    Francois, B
    VanCaillieBertrand, M
    Herchuelz, A
    Vanovervelt, N
    VanHoorebeke, C
    Vanden Berghe, DA
    [J]. EXPERIENTIA, 1995, 51 (12): : 1208 - 1215