CDK inhibition and cancer therapy

被引：143

作者：

Garrett, MD ^{[1
]}

Fattaey, A ^{[1
]}

机构：

[1] Onyx Pharmaceut, Richmond, CA 94806 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(99)80015-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cell-division cycle is a tightly controlled process that is regulated by the cyclin/CDK family of protein kinase complexes. Stringent control of this process is essential to ensure that DNA synthesis and subsequent mitotic division are accurately and coordinately executed. There is now strong evidence that CDKs, their regulators, and substrates are the targets of genetic alteration in many human cancers. As a result of this, the CDKs have been targeted for drug discovery and a number of small molecule inhibitors of CDKs have been identified.

引用

页码：104 / 111

页数：8

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