Age-related effects of vagotonic atropine on cardiovagal baroreflex gain

被引:7
作者
Callegaro, Carine C. [1 ]
Taylor, J. Andrew [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Phys Med & Rehabil, Spaulding Rehabil Hosp,Cardiovasc Res Lab, Boston, MA 02114 USA
基金
美国国家卫生研究院;
关键词
Aging; Older; Vagal; Parasympathetic; HEART-RATE-VARIABILITY; ARTERIAL BAROREFLEX; MYOCARDIAL-INFARCTION; SENSITIVITY; MODULATION; OLDER; RATS; DISTENSIBILITY; MORTALITY; DECLINES;
D O I
10.1016/j.neurobiolaging.2010.03.018
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Impaired neural transduction of barosensory vessel stretch into vagal outflow is a primary determinant of reduced cardiovagal baroreflex gain with human aging. We set out to determine whether age-related reductions in this neural component of the baroreflex might be offset by enhancing the central integration/efferent responsiveness of the neural arc. Low vagotonic doses of atropine were employed to enhance central neural outflow and peripheral sinus node effects. Baroreflex gain and its neural and mechanical components were pharmacologically assessed before and after intravenous vagotonic atropine in 16 older and 14 young healthy subjects. Vagotonic atropine increased cardiovagal baroreflex gain (similar to 30%) and its neural component (similar to 20%) in older but not young individuals. Moreover, the atropine-induced increases in integrated gain and in its neural component were inversely related to baseline levels. Thus, age-related neural deficits in the baroreflex arc appear to play a determining role in reduced cardiovagal baroreflex gain with age and the compromised neural baroreflex function can be acutely improved by a single pharmacologic intervention. (C) 2012 Published by Elsevier Inc.
引用
收藏
页码:368 / 374
页数:7
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