Pharmaceutical applications of some Spanish clays (sepiolite, palygorskite, bentonite): some preformulation studies

In this work, a pharmaceutical preformulation study of four Spanish days (two sepiolites, one palygorskite and one bentonite) is presented, comparing the results obtained with those of three mineral products currently used in pharmaceutical technology. The results showed that the mineralogical and chemical purity of these clays is similar and even higher than that of the three commercial products. The microorganism content is inside the range required for non-sterile pharmaceutical forms. We also determined two parameters concerning the clays' suitability for use in tablet manufacture (colour and water content) and one indicating appropriateness as an antidiarrheic product (adsorption capacity of methylene blue). The clays are yellowish white in colour, although correction does not seem necessary; water content varies according to the structure of the clay and storage conditions. Adsorption capacity of methylene blue is affected by the amount of hydration water present, dehydration temperature and the type of interchangeable cation found in the clay. (C) 1999 Elsevier Science B.V. All rights reserved.