Neuroprotective action of proline-rich polypeptide-1 in β-amyloid induced neurodegeneration in rats

被引：30

作者：

Yenkoyan, Konstantin ^{[1
]}

Safaryan, Karen ^{[2
]}

Chavushyan, Vergine ^{[3
]}

Meliksetyan, Irina ^{[4
]}

Navasardyan, Grizelda ^{[5
]}

Sarkissian, John ^{[3
]}

Galoyan, Armen ^{[6
]}

Aghajanov, Michail ^{[1
]}

机构：

[1] Yerevan State Med Univ M Heratsi, Dept Biochem, Yerevan 0025, Armenia

[2] Univ Hertfordshire, Biol & Neural Computat Grp, Hatfield AL10 9AB, Herts, England

[3] NAS RA, L Orbeli Inst Physiol, Lab Physiol Compensat CNS Funct, Yerevan, Armenia

[4] NAS RA, L Orbeli Inst Physiol, Neuromorphol Lab, Yerevan, Armenia

[5] Yerevan State Med Univ M Heratsi, Dept Pathophysiol, Yerevan 0025, Armenia

[6] NAS RA, H Buniatyan Inst Biochem, Lab Neurohormones, Yerevan, Armenia

来源：

BRAIN RESEARCH BULLETIN | 2011年 / 86卷 / 3-4期

关键词：

Neurodegeneration; beta-Amyloid; PRP-1; Neuroprotection; ALZHEIMERS-DISEASE; HYPOTHALAMIC PEPTIDE; SYNAPTIC PLASTICITY; MOLECULAR-BASIS; MEMORY; BRAIN; OLIGOMERS; INHIBITION; PATHOLOGY; SYNAPSES;

D O I：

10.1016/j.brainresbull.2011.08.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It is recognized that the main trigger of Alzheimer disease related neurodegeneration is beta-amyloid peptide, which subsequently generates different metabolic disorders in neuron and finally leads to neuronal death. Several biologically active products were tested as neuroprotectors, but only few of them demonstrated any efficiency. Proline-rich polypeptide-1 was tested as a neuroprotective agent on A beta 25-35 animal model of Alzheimer disease. Biochemical analysis (determination of spectrum of neuroactive amino acids, such as glutamate, gamma-aminobutyric acid, glycine, aspartate and taurine), as well as behavioral, electrophysiological and morphological studies were performed to reveal the neuroprotective potential of proline-rich polypeptide in rats. Based on the results of our study it can be concluded that praline-rich polypeptide-1 has a potential to be one of the effective preventive or therapeutic agents against neurodegenerative disorders, such as Alzheimer disease. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：262 / 271

页数：10

共 42 条

[1] Immunohistochemical study of immunophilin 1-15 fragment in intact frog brain, and in the brain and spinal cord of intact and spinal cord hemisectioned rats [J].

Abrahamyan, SS ;

Meliksetyan, IB ;

Sulkhanyan, RM ;

Sarkissian, JS ;

Galoyan, AA .

NEUROCHEMICAL RESEARCH, 2001, 26 (11) :1225-1230

[2] Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment [J].

Conrad, CD ;

Galea, LAM ;

Kuroda, Y ;

McEwen, BS .

BEHAVIORAL NEUROSCIENCE, 1996, 110 (06) :1321-1334

[3] Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers [J].

De Felice, Fernanda G. ;

Vieira, Marcelo N. N. ;

Bomfim, Theresa R. ;

Decker, Helena ;

Velasco, Pauline T. ;

Lambert, Mary P. ;

Viola, Kirsten L. ;

Zhao, Wei-Qin ;

Ferreira, Sergio T. ;

Klein, William L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (06) :1971-1976

[4] Roles for short-term synaptic plasticity in behavior [J].

Fortune, ES ;

Rose, GJ .

JOURNAL OF PHYSIOLOGY-PARIS, 2002, 96 (5-6) :539-545

[5] Hypothalamic proline-rich polypeptide protects brain neurons in aluminum neurotoxicosis [J].

Galoyan, AA ;

Shakhlamov, VA ;

Aghajanov, MI ;

Vahradyan, HG .

NEUROCHEMICAL RESEARCH, 2004, 29 (07) :1349-1357

[6] Protective effect of a new hypothalamic peptide against cobra venom and trauma-induced neuronal injury [J].

Galoyan, AA ;

Sarkissian, JS ;

Kipriyan, TK ;

Sarkissian, EJ ;

Chavushyan, EA ;

Sulkhanyan, RM ;

Meliksetyan, IB ;

Abrahamyan, SS ;

Grigorian, YK ;

Avetisyan, ZA ;

Otieva, NA .

NEUROCHEMICAL RESEARCH, 2001, 26 (8-9) :1023-1038

[7]

GALOYAN AA, 2004, BRAIN NEUROSECRETORY, P188

[8] Neuroprotection by hypothalamic peptide proline-rich peptide-1 in Aβ25-35 model of Alzheimer's disease [J].

Galoyan, Armen A. ;

Sarkissian, John S. ;

Chavushyan, Vergineh A. ;

Meliksetyan, Irina B. ;

Avagyan, Zaruhi E. ;

Poghosyan, Mikhail V. ;

Vahradyan, Hasmik G. ;

Mkrtchian, Hovhannes H. ;

Abrahamyan, Davit O. .

ALZHEIMERS & DEMENTIA, 2008, 4 (05) :332-344

[9] Proline-rich polypeptides in Alzheimer's disease and neurodegenerative disorders - Therapeutic potential or a mirage? [J].

Gladkevich, A. ;

Bosker, F. ;

Korf, J. ;

Yenkoyan, K. ;

Vahradyan, H. ;

Aghajanov, M. .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2007, 31 (07) :1347-1355

[10]

Golde Todd E., 2006, Current Alzheimer Research, V3, P421, DOI 10.2174/156720506779025189

← 1 2 3 4 5 →