Exploratory predictive and prognostic factors in advanced breast cancer treated with metronomic chemotherapy

被引：13

作者：

Miscoria, Manuela ^{[1
]}

Tonetto, Fabrizio ^{[1
]}

Deroma, Laura ^{[2
]}

Machin, Piernicola ^{[3
]}

Di Loreto, Carla ^{[3
]}

Driol, Pamela ^{[1
]}

Minisini, Alessandro Marco ^{[1
]}

Russo, Stefania ^{[1
]}

Andreetta, Claudia ^{[1
]}

Mansutti, Mauro ^{[1
]}

Damante, Giuseppe ^{[4
]}

Fasola, Gianpiero ^{[1
]}

Puglisi, Fabio ^{[1
]}

机构：

[1] Univ Udine, Dept Oncol, I-33100 Udine, Italy

[2] Univ Udine, Reg Coordinat Ctr Rare Dis, I-33100 Udine, Italy

[3] Univ Udine, Dept Pathol, I-33100 Udine, Italy

[4] Univ Udine, Dept Genet, I-33100 Udine, Italy

来源：

ANTI-CANCER DRUGS | 2012年 / 23卷 / 03期

关键词：

advanced breast cancer; angiogenesis; metronomic chemotherapy; prognosis; THYMIDINE PHOSPHORYLASE EXPRESSION; ENDOTHELIAL GROWTH-FACTOR; ANTITUMOR-ACTIVITY; CYCLOPHOSPHAMIDE; METHOTREXATE; BEVACIZUMAB; PROGRESSION; SURVIVAL; BENEFIT; ANGIOGENESIS;

D O I：

10.1097/CAD.0b013e32834e735a

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of the present study is to evaluate the clinical and biological factors (including markers of angiogenesis) as potential predictors of prognosis and benefit from metronomic therapy in patients with advanced breast cancer (ABC). Recent data suggest antiangiogenic activity of metronomic therapy. The study population included 62 patients with pretreated ABC who received cyclophosphamide and methotrexate orally. Tumour samples were analysed by immunohistochemistry for HER2, Ki-67, thymidine phosphorylase (TP), vascular endothelial growth factor and vascular endothelial growth factor receptor. The results from immunohistochemical analysis and clinico-pathological variables were studied to test their potential association with benefit from metronomic therapy. The median overall survival, progression-free survival and survival postprogression were 7.1 (range 0.2-38.3), 2.6 (range 0.2-28.9) and 3 (range 0-34.2) months, respectively. Among the clinical variables, age, performance status and previous therapy with taxanes were significantly associated with outcomes. Among the molecular markers, TP was found to be associated with progression-free survival. Metronomic therapy is an effective choice for ABC. Young women with a more indolent disease had the greatest benefit from this treatment. TP tumour expression might aid decision making but these findings must be confirmed in larger prospective, properly designed studies. Anti-Cancer Drugs 23: 326-334 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：326 / 334

页数：9

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