Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis

被引：79

作者：

Birks, Laura ^{[1
,2
,3
]}

Casas, Maribel ^{[1
,2
,3
]}

Garcia, Ana M. ^{[2
,4
,5
]}

Alexander, Jan ^{[6
]}

Barros, Henrique ^{[7
]}

Bergstrom, Anna ^{[8
]}

Bonde, Jens Peter ^{[9
]}

Burdorf, Alex ^{[10
]}

Costet, Nathalie ^{[11
]}

Danileviciute, Asta ^{[12
]}

Eggesbo, Merete ^{[6
]}

Fernandez, Mariana F. ^{[2
,13
]}

Gonzalez-Galarzo, M. Carmen ^{[4
]}

Grazuleviciene, Regina ^{[12
]}

Hanke, Wojciech ^{[14
]}

Jaddoe, Vincent ^{[15
]}

Kogevinas, Manolis ^{[1
,2
,16
,17
]}

Kull, Inger ^{[18
,19
]}

Lertxundi, Aitana ^{[20
,21
]}

Melaki, Vasiliki ^{[22
]}

Andersen, Anne-Marie Nybo ^{[23
]}

Olea, Nicols ^{[2
,13
]}

Polanska, Kinga ^{[14
]}

Rusconi, Franca ^{[24
]}

Santa-Marina, Loreto ^{[2
,23
,25
]}

Santos, Ana Cristina

Vrijkotte, Tanja ^{[26
]}

Zugna, Daniela ^{[27
]}

Nieuwenhuijsen, Mark ^{[1
,2
,3
]}

Cordier, Sylvaine ^{[11
]}

Vrijheid, Martine ^{[1
,2
,3
]}

机构：

[1] ISGlobal, Ctr Res Environm Epidemiol, Doctor Aiguader 88, Barcelona 08003, Spain

[2] Consorcio Invest Biomed Epidemiol & Salud Publ, Barcelona, Spain

[3] Univ Pompeu Fabra, Barcelona, Spain

[4] Univ Valencia, Dept Prevent Med & Publ Hlth, Valencia, Spain

[5] Ctr Res Occupat Hlth, Barcelona, Spain

[6] Norwegian Inst Publ Hlth, Oslo, Norway

[7] Univ Porto, Sch Med, Dept Clin Epidemiol Predict Med & Publ Hlth, Porto, Portugal

[8] Karolinska Inst, Inst Environm Med, Stockholm, Sweden

[9] Univ Copenhagen, Dept Occupat & Environm Med, Bispebjerg Hosp, Copenhagen, Denmark

[10] Erasmus Univ, Dept Publ Hlth, Med Ctr, Rotterdam, Netherlands

[11] Univ Rennes, Natl Inst Hlth & Med Res, Irset InsermU1085, Rennes, France

[12] Vytautas Magnus Univ, Dept Environm Sci, Kaunas, Lithuania

[13] Univ Granada, Inst Invest Biosanitaria Ibs Granada, Granada, Spain

[14] Nofer Inst Occupat Med, Dept Environm Epidemiol, Lodz, Poland

[15] Erasmus Univ, Dept Epidemiol, Dept Pediat, Med Ctr,Generat R Study Grp, Rotterdam, Netherlands

[16] Hosp Del Mar, Med Res Inst, Barcelona, Spain

[17] Natl Sch Publ Hlth, Athens, Greece

[18] Soder Sjukhuset, Sachs Childrens Hosp, Stockholm, Sweden

[19] Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden

[20] Univ Basque Country, Fac Med, Leioa, Basque Country, Spain

[21] BioDonostia Hlth Res Inst, San Sebastian, Basque Country, Spain

[22] Univ Crete, Univ Hosp Heraklion, Dept Social Med, Fac Med, Iraklion, Greece

[23] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark

[24] Meyer Childrens Univ Hosp, Florence, Italy

[25] Govt Basque Country, Dept Hlth, San Sebastian, Spain

[26] Univ Amsterdam, Acad Med Ctr, Dept Publ Hlth, Amsterdam, Netherlands

[27] Univ Turin, Dept Med Sci, Canc Epidemiol Unit, Turin, Italy

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 2016年 / 124卷 / 11期

基金：

瑞典研究理事会; 美国国家卫生研究院; 欧洲研究理事会;

关键词：

POLYCYCLIC AROMATIC-HYDROCARBONS; PRENATAL EXPOSURE; FETAL-GROWTH; PRETERM DELIVERY; BISPHENOL-A; PREGNANCY; IMPACT; HETEROGENEITY; ASSOCIATIONS; PHENOLS;

D O I：

10.1289/EHP208

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

BACKGROUND: Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth. OBJECTIVES: We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery. METHODS: Using individual participant data from 133,957 mother-child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates. RESULTS: Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p < 0.05) with the other outcomes; women holding job titles classified as exposed to bisphenol A or brominated flame retardants were at higher risk for longer length of gestation. CONCLUSION: Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW.

引用

页码：1785 / 1793

页数：9

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