OLR1 is a prognostic factor and correlated with immune infiltration in breast cancer

被引：20
作者：
Sun, Xiangyu [1 ]
Fu, Xin [2 ]
Xu, Shouping [3 ]
Qiu, Pengfei [4 ]
Lv, Zhidong [5 ]
Cui, Mingke [2 ]
Zhang, Qiang [2 ]
Xu, Yingying [1 ]
机构：
[1] China Med Univ, Dept Breast Surg, Affiliated Hosp 1, Shenyang, Liaoning, Peoples R China
[2] China Med Univ, Liaoning Canc Hosp & Inst, Dept Breast Surg, Canc Hosp, Shenyang, Liaoning, Peoples R China
[3] Harbin Med Univ, Dept Breast Surg, Canc Hosp, Harbin, Heilongjiang, Peoples R China
[4] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Breast Canc Ctr, Jinan, Shandong, Peoples R China
[5] Qingdao Univ, Breast Ctr, Affiliated Hosp, Qingdao, Shandong, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2021年 / 101卷
基金：
中国国家自然科学基金;
关键词：
Prognosis; Breast cancer; Immune infiltration; Biomarker; TUMOR-ASSOCIATED MACROPHAGES; EXPRESSION; METABOLISM; PROMOTES;
D O I：
10.1016/j.intimp.2021.108275
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Oxidized low-density lipoprotein receptor 1 (OLR1), a key receptor for oxidized low-density lipoprotein (oxLDL), plays a crucial role in cancer and inflammatory disease. However, the correlation between OLR1 expression and immune infiltration in breast cancer (BC) remain unclear. In this study, we comprehensively analyzed the expression level of OLR1 in BC tissues and explore the prognostic importance of OLR1 using quantitative real-time PCR, immunohistochemical analysis and different databases. The significantly enriched KEGG and GO pathways were used to identify the potential biological function of OLR1 via LinkedOmics analysis. Furthermore, we detected the correlation between OLR1 expression and a variety of immune infiltrating cells via Tumor Immune Estimation Resource database and GEPIA database. Our study revealed that OLR1 upregulation was observed in BC tissues and correlated with worse clinical outcomes and advanced clinicopathological factors. Meanwhile, OLR1 regulated various immunity-related pathways, especially the polarization of macrophages. Immunohistochemical analysis further confirmed the significant correlation between OLR1 expression and tumor infiltration of M2 macrophages as well as tumor-associated macrophages. OLR1 upregulation indicated poor prognosis in BC, possibly through inducing macrophage polarization and triggering immune evasion. Collectively, OLR1 may represent a potential therapeutic target for BC tailored therapy.
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页数：11
相关论文
共 33 条
[11]   Oxidized low density lipoprotein receptor 1 promotes lung metastases of osteosarcomas through regulating the epithelial-mesenchymal transition [J].
Jiang, Long ;
Jiang, Shanshan ;
Zhou, Wenjie ;
Huang, Jia ;
Lin, Yongbin ;
Long, Hao ;
Luo, Qingquan .
JOURNAL OF TRANSLATIONAL MEDICINE, 2019, 17 (01)
[12]  
Kidd Parris, 2003, Altern Med Rev, V8, P223
[13]   Clinical significance of signal regulatory protein alpha (SIRPα) expression in esophageal squamous cell carcinoma [J].
Koga, Naomichi ;
Hu, Qingjiang ;
Sakai, Akihiro ;
Takada, Kazuki ;
Nakanishi, Ryota ;
Hisamatsu, Yuichi ;
Ando, Koji ;
Kimura, Yasue ;
Oki, Eiji ;
Oda, Yoshinao ;
Mori, Masaki .
CANCER SCIENCE, 2021, 112 (08) :3018-3028
[14]   Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy [J].
Lei, Xu ;
Lei, Yu ;
Li, Jin-Ke ;
Du, Wei-Xing ;
Li, Ru-Gui ;
Yang, Jing ;
Li, Jian ;
Li, Fang ;
Tan, Hua-Bing .
CANCER LETTERS, 2020, 470 :126-133
[15]   TIMER2.0 for analysis of tumor-infiltrating immune cells [J].
Li, Taiwen ;
Fu, Jingxin ;
Zeng, Zexian ;
Cohen, David ;
Li, Jing ;
Chen, Qianming ;
Li, Bo ;
Liu, X. Shirley .
NUCLEIC ACIDS RESEARCH, 2020, 48 (W1) :W509-W514
[16]   Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes [J].
Mantovani, A ;
Sozzani, S ;
Locati, M ;
Allavena, P ;
Sica, A .
TRENDS IN IMMUNOLOGY, 2002, 23 (11) :549-555
[17]   LOX-1 and cancer: an indissoluble liaison [J].
Murdocca, M. ;
De Masi, C. ;
Pucci, S. ;
Mango, R. ;
Novelli, G. ;
Di Natale, C. ;
Sangiuolo, F. .
CANCER GENE THERAPY, 2021, 28 (10-11) :1088-1098
[18]   Targeting Tumor-Associated Macrophages in Cancer [J].
Pathria, Paulina ;
Louis, Tiani L. ;
Varner, Judith A. .
TRENDS IN IMMUNOLOGY, 2019, 40 (04) :310-327
[19]   LOX-1, OxLDL, and Atherosclerosis [J].
Pirillo, Angela ;
Norata, Giuseppe Danilo ;
Catapano, Alberico Luigi .
MEDIATORS OF INFLAMMATION, 2013, 2013
[20]   Pro-oncogenic action of LOX-1 and its splice variant LOX-1Δ4 in breast cancer phenotypes [J].
Pucci, Sabina ;
Polidoro, Chiara ;
Greggi, Chiara ;
Amati, Francesca ;
Morini, Elena ;
Murdocca, Michela ;
Biancolella, Michela ;
Orlandi, Augusto ;
Sangiuolo, Federica ;
Novelli, Giuseppe .
CELL DEATH & DISEASE, 2019, 10 (2)
1234