Effects of Leisure-Time Physical Activity on Cognitive Reserve Biomarkers and Leisure Motivation in the Pre-Diabetes Elderly

被引:7
作者
Kim, Bo-Ram [1 ]
Lim, Seung-Taek [2 ]
机构
[1] Korea Univ, Coll Educ, Dept Phys Educ, Seoul 02841, South Korea
[2] Kangwon Natl Univ, Olymp Studies Ctr, Chuncheon Si 24341, South Korea
基金
新加坡国家研究基金会;
关键词
prediabetes; elderly; physical activity; leisure-time; cognitive; biomarkers; AEROBIC EXERCISE; ALZHEIMERS-DISEASE; CATHEPSIN-B; ASSOCIATION; PLASMA; MODALITIES; DEMENTIA; RISK;
D O I
10.3390/healthcare10040737
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
The purpose of this study was to investigate the change in cognitive reserve biomarkers of the pre-diabetic individual according to the types of leisure-time physical activity (aerobic or resistance physical activity). The research subjects (n = 184) who participated in the survey were pre-diabetic and diabetic patients who were visiting university hospitals and welfare centers. The intervention subjects (n = 36) who were elderly females with pre-diabetes volunteered to participate in the study by performing regular physical exercise (aerobic or resistance exercise). The study participants were 65 years of age or older with pre-diabetes defined by a glycated hemoglobin (HbA1c) level of (5.7-6.4)%. All research subjects performed motivation and stress questionnaire survey. All intervention subjects participated in leisure-time physical activity (LTPA) for 12 weeks. Body composition, HbA1c, and cognitive reserve biomarkers were measured at baseline, and at 6 and 12 weeks. LTPA motivation confirmed that the LTPA participants had a high level of motivation. Stress confirmed that the stress level of LTPA participants was low. Two-way within-factor ANOVA revealed significant group x time interaction for weight (p < 0.05), BMI (p < 0.01), % fat (p < 0.001), SBP (p < 0.05), HbA1c (p < 0.001), BDNF (p < 0.001), and Beta-Amyloid 1-42 (p < 0.001). In both physical activity groups, HbA1c (p < 0.001), NGF (p < 0.05), BDNF (p < 0.05), and Cathepsin B (p < 0.05) improved significantly at 12 weeks, compared to baseline and 6 weeks. In the resistance physical activity group, Beta-Amyloid 1-42 (p < 0.01) and Homocysteine (p < 0.05) significantly decreased at 12 weeks, compared to baseline and at 6 weeks. The LTPA showed high levels of integrated and identified regulation among leisure motive types, and the level of stress was found to be low. The LTPA is effective in reducing the HbA1c levels of the pre-diabetes elderly. In addition, the pre-diabetes elderly were found to have increased NGF, BDNF, and cathepsin B, and decreased Beta-Amyloid 1-42 and homocysteine. Regular leisure-time physical activity has a positive effect on cognitive reserve biomarkers through improving glycemic control by reducing weight and % fat in the pre-diabetes elderly.
引用
收藏
页数:12
相关论文
共 50 条
[41]   Perceived Barriers to Leisure-time Physical Activity among Individuals at Risk of Type 2 Diabetes in India [J].
Thirunavukkarasu, Sathish ;
El Fil, Farah ;
Prokou, Maria ;
Venkatachalam, Aravind ;
Kumar, Siya ;
Shifaly, Fathimath ;
Oldenburg, Brian .
JOURNAL OF DIABETOLOGY, 2024, 15 (04) :395-400
[42]   Constraints to leisure-time physical activity among Brazilian workers [J].
Andrade, Rubian Diego ;
Ferrari Junior, Geraldo Jose ;
Capistrano, Renata ;
Beltrame, Thais Silva ;
Pelegrini, Andreia ;
Crawford, Duane W. ;
Gomes Felden, Erico Pereira .
ANNALS OF LEISURE RESEARCH, 2019, 22 (02) :202-214
[43]   Leisure-Time Physical Activity and Obesity Risk in Adults in Mexico [J].
Petermann-Rocha, Fanny ;
Apolinar-Jimenez, Evelia ;
Ferrari, Gerson ;
Medina, Catalina ;
O'Donovan, Gary .
AMERICAN JOURNAL OF PREVENTIVE MEDICINE, 2025, 68 (05) :989-997
[44]   Relationship of leisure-time physical activity and occupational activity to the prevalence of obesity [J].
King, GA ;
Fitzhugh, EC ;
Bassett, DR ;
McLaughlin, JE ;
Strath, SJ ;
Swartz, AM ;
Thompson, DL .
INTERNATIONAL JOURNAL OF OBESITY, 2001, 25 (05) :606-612
[45]   Occupational and leisure-time physical activity and coronary heart disease [J].
Holtermann, Andreas .
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2015, 72 (09) :615-616
[46]   Relationship of leisure-time physical activity and occupational activity to the prevalence of obesity [J].
GA King ;
EC Fitzhugh ;
DR Bassett Jr ;
JE McLaughlin ;
SJ Strath ;
AM Swartz ;
DL Thompson .
International Journal of Obesity, 2001, 25 :606-612
[47]   Correlates of Leisure-Time Physical Activity During Transitions to Motherhood [J].
McIntyre, Carolyn A. ;
Rhodes, Ryan E. .
WOMEN & HEALTH, 2009, 49 (01) :66-83
[48]   Intensity of leisure-time physical activity and cancer mortality in men [J].
Laukkanen, J. A. ;
Rauramaa, R. ;
Makikallio, T. H. ;
Toriola, A. T. ;
Kurl, S. .
BRITISH JOURNAL OF SPORTS MEDICINE, 2011, 45 (02) :125-129
[50]   Seasonal Variation in Leisure-time Physical Activity Among Canadians [J].
Anwar T. Merchant ;
Mahshid Dehghan ;
Noori Akhtar-Danesh .
Canadian Journal of Public Health, 2007, 98 :203-208