Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents

被引：36

作者：

Hong, Yu ^{[1
]}

Zhu, Yuan-Yuan ^{[1
]}

He, Qiuqin ^{[2
]}

Gu, Shuang-Xi ^{[3
]}

机构：

[1] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Peoples R China

[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[3] Wuhan Inst Technol, Sch Chem Engn & Pharm, Minist Educ, Key Lab Green Chem Proc, Wuhan 430205, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2022年 / 55卷

基金：

中国国家自然科学基金;

关键词：

Anticancer; Indole derivatives; Microtubules; Tubulin polymerization inhibitors; Colchicine binding site; MICROWAVE-ASSISTED SYNTHESIS; BIOLOGICAL EVALUATION; IN-VITRO; ANTITUMOR-ACTIVITY; MOLECULAR DOCKING; TARGETING TUBULIN; BINDING-SITE; COMBRETASTATIN A-4; CYTOTOXIC ACTIVITY; STRUCTURAL BASIS;

D O I：

10.1016/j.bmc.2021.116597

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The alpha-and beta-tubulins are the major polypeptide components of microtubules (MTs), which are attractive targets for anticancer drug development. Indole derivatives display a variety of biological activities including antitumor activity. In recent years, a great number of indole derivatives as tubulin polymerization inhibitors have sprung up, which encourages medicinal chemists to pursue promising inhibitors with improved antitumor activities, excellent physicochemical, pharmacokinetic and pharmacodynamic properties. In this review, the recent progress from 2010 to present in the development of indole derivatives as tubulin polymerization inhibitors was summarized and reviewed, which would provide useful clues and inspirations for further design of outstanding tubulin polymerization inhibitors.

引用

页数：21

共 137 条

[1] Synthesis and antibacterial activity of some substituted 3-(aryl)- and 3-(heteroaryl)indoles [J].

Al-Hiari, YM ;

Qaisi, AM ;

El-Abadelah, MM ;

Voelter, W .

MONATSHEFTE FUR CHEMIE, 2006, 137 (02) :243-248

[2] Heterocyclic Scaffolds: Centrality in Anticancer Drug Development [J].

Ali, Imran ;

Lone, Mohammad Nadeem ;

Al-Othman, Zeid A. ;

Al-Warthan, Abdulrahman ;

Sanagi, Mohd Marsin .

CURRENT DRUG TARGETS, 2015, 16 (07) :711-734

[3] The selenium to selenoprotein pathway in eukaryotes: More molecular partners than anticipated [J].

Allmang, Christine ;

Wurth, Laurence ;

Krol, Alain .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2009, 1790 (11) :1415-1423

[4] Recent advances in ionic liquids and nanotechnology for drug delivery [J].

Amaral, Mariana ;

Pereiro, Ana B. ;

Gaspar, Maria Manuela ;

Reis, Catarina Pinto .

NANOMEDICINE, 2020, 16 (01) :63-80

[5] Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and Analogues: Synthesis, Cytotoxic Activity, and Study of the Mechanism of Action [J].

Andreani, Aldo ;

Granaiola, Massimiliano ;

Locatelli, Alessandra ;

Morigi, Rita ;

Rambaldi, Mirella ;

Varoli, Lucilla ;

Calonghi, Natalia ;

Cappadone, Concettina ;

Farruggia, Giovanna ;

Stefanelli, Claudio ;

Masotti, Lanfranco ;

Nguyen, Tam L. ;

Hamel, Ernest ;

Shoemaker, Robert H. .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (05) :2078-2088

[6] Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and 3-(5-Imidazo[2,1-b]thiadiazolylmethylene)-2-indolinones: Selectivity against Colon Tumor Cells and Effect on Cell Cycle-Related Events [J].

Andreani, Aldo ;

Burnelli, Silvia ;

Granaiola, Massimiliano ;

Leoni, Alberto ;

Locatelli, Alessandra ;

Morigi, Rita ;

Rambaldi, Mirella ;

Varoli, Lucilla ;

Calonghi, Natalia ;

Cappadone, Concettina ;

Voltattomi, Manuela ;

Zini, Maddalena ;

Stefanelli, Claudio ;

Masotti, Lanfranco ;

Shoemaker, Robert H. .

JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (23) :7508-7513

[7] The interaction of baccatin III with the taxol binding site of microtubules determined by a homogeneous assay with fluorescent taxoid [J].

Andreu, JM ;

Barasoain, I .

BIOCHEMISTRY, 2001, 40 (40) :11975-11984

[8] Advanced Drug Delivery Systems of Curcumin for Cancer Chemoprevention [J].

Bansal, Shyam S. ;

Goel, Mehak ;

Aqil, Farrukh ;

Vadhanam, Manicka V. ;

Gupta, Ramesh C. .

CANCER PREVENTION RESEARCH, 2011, 4 (08) :1158-1171

[9] Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors [J].

Baytas, Sultan Nacak ;

Inceler, Nazan ;

Yilmaz, Akin ;

Olgac, Abdurrahman ;

Menevse, Sevda ;

Banoglu, Erden ;

Hamel, Ernest ;

Bortolozzi, Roberta ;

Viola, Giampietro .

BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 22 (12) :3096-3104

[10] A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivo glioblastoma models [J].

Boumendjel, Ahcene ;

McLeer-Florin, Anne ;

Champelovier, Pierre ;

Allegro, Diane ;

Muhammad, Dima ;

Souard, Florence ;

Derouazi, Madiha ;

Peyrot, Vincent ;

Toussaint, Bertrand ;

Boutonnat, Jean .

BMC CANCER, 2009, 9

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