A guide to immunometabolism for immunologists

被引：2118

作者：

O'Neill, Luke A. J. ^{[1
]}

Kishton, Rigel J. ^{[2
]}

Rathmell, Jeff ^{[2
]}

机构：

[1] Trinity Coll Dublin, Sch Biochem & Immunol, Trinity Biomed Sci Inst, Dublin 2, Ireland

[2] Vanderbilt Univ, Med Ctr, Vanderbilt Ctr Immunobiol, Dept Pathol Microbiol & Immunol, Nashville, TN 37232 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 09期

基金：

欧洲研究理事会; 爱尔兰科学基金会; 英国惠康基金;

关键词：

FATTY-ACID OXIDATION; T-REG CELLS; PULMONARY INDOLEAMINE 2,3-DIOXYGENASE; NLRP3 INFLAMMASOME ACTIVATION; NITRIC-OXIDE SYNTHASE; PYRUVATE-KINASE M2; MACROPHAGE POLARIZATION; MURINE MACROPHAGES; EFFECTOR FUNCTION; L-ARGININE;

D O I：

10.1038/nri.2016.70

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years a substantial number of findings have been made in the area of immunometabolism, by which we mean the changes in intracellular metabolic pathways in immune cells that alter their function. Here, we provide a brief refresher course on six of the major metabolic pathways involved (specifically, glycolysis, the tricarboxylic acid (TCA) cycle, the pentose phosphate pathway, fatty acid oxidation, fatty acid synthesis and amino acid metabolism), giving specific examples of how precise changes in the metabolites of these pathways shape the immune cell response. What is emerging is a complex interplay between metabolic reprogramming and immunity, which is providing an extra dimension to our understanding of the immune system in health and disease.

引用

页码：553 / 565

页数：13

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