Emerging Roles of Protein Kinase D1 in Cancer

被引：63
作者：
Sundram, Vasudha [1 ]
Chauhan, Subhash C. [1 ,2 ,3 ]
Jaggi, Meena [1 ,2 ,3 ]
机构：
[1] Univ S Dakota, Canc Biol Res Ctr, Sanford Res USD, Sanford Sch Med, Sioux Falls, SD 57105 USA
[2] Univ S Dakota, Dept Obstet & Gynaecol, Sanford Sch Med, Sioux Falls, SD 57105 USA
[3] Univ S Dakota, Dept Basic Biomed Sci, Sanford Sch Med, Sioux Falls, SD 57105 USA
来源：
MOLECULAR CANCER RESEARCH | 2011年 / 9卷 / 08期
关键词：
MATRIX-METALLOPROTEINASE EXPRESSION; PROSTATE-CANCER; ANDROGEN RECEPTOR; BETA-CATENIN; E-CADHERIN; PKC-MU; SUBCELLULAR-LOCALIZATION; CATALYTIC ACTIVATION; CELL-PROLIFERATION; C-MU;
D O I：
10.1158/1541-7786.MCR-10-0365
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Protein kinase D1 (PKD1) is a serine-threonine kinase that regulates various functions within the cell, including cell proliferation, apoptosis, adhesion, and cell motility. In normal cells, this protein plays key roles in multiple signaling pathways by relaying information from the extracellular environment and/or upstream kinases and converting them into a regulated intracellular response. The aberrant expression of PKD1 is associated with enhanced cancer phenotypes, such as deregulated cell proliferation, survival, motility, and epithelial mesenchymal transition. In this review, we summarize the structural and functional aspects of PKD1 and highlight the pathobiological roles of this kinase in cancer. Mol Cancer Res; 9(8); 985-96. (C)2011 AACR.
引用
收藏
页码：985 / 996
页数：12
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