Interference in free thyroxine immunoassay

被引：13
作者：
Ghosh, Sujoy [1 ]
Howlett, Michael
Boag, David
Malik, Iqbal [1 ]
Collier, Andrew [1 ]
机构：
[1] Ayr Hosp, Ayr KA6 6DX, Scotland
来源：
EUROPEAN JOURNAL OF INTERNAL MEDICINE | 2008年 / 19卷 / 03期
关键词：
heterophile antibodies; free thyroxine; immunoassay;
D O I：
10.1016/j.ejim.2007.05.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report two patients who presented with non-specific symptoms of tiredness that prompted their clinician to order a thyroid function test. In both cases, free thyroxine (T4) was reported to be high, with a normal thyroid-stimulating hormone (TSH). Repeated blood tests from the same laboratory using the same assay method yielded similar results. Due to discrepancies between the clinical and laboratory findings, we decided to repeat the blood tests at another laboratory using a different assay method. This revealed normal free T4 and TSH levels, suggesting that heterophile antibodies were interfering with the free T4 assay, leading to clinical confusion. (C) 2007 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
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收藏
页码：221 / 222
页数：2
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