Allopurinol augmentation for poorly responsive schizophrenia

被引：45
作者：
Lara, DR
Brunstein, MG
Ghisolfi, ES
Lobato, MI
Belmonte-de-Abreu, P
Souza, DO
机构：
[1] UFRGS, ICBS, Dept Bioquim, BR-90035003 Porto Alegre, RS, Brazil
[2] PUC RS, Fac Biosci, Dept Biochem, Porto Alegre, RS, Brazil
[3] UFRGS, HCPA, Dept Psychiat, Porto Alegre, RS, Brazil
来源：
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 2001年 / 16卷 / 04期
关键词：
allopurinol; adenosine; purinergic system; schizophrenia;
D O I：
10.1097/00004850-200107000-00008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Adenosine has been proposed to contribute to the pathophysiology of schizoprenia and as a target for therapeutic intervention. In the lack of direct adenosine agonists, allopurinol may indirectly elevate adenosine levels by inhibiting degradation of purines. We report two cases of poorly responsive schizophrenic patients who improved considerably with add-on allopurinol 300 mg / day. Their clear clinical improvement warrant further investigation of allopurinol, as well as other purinergic strategies, for the treatment of schizophrenia. (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码：235 / 237
页数：3
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