Development of Newborn and Infant Vaccines

被引：53
作者：
Sanchez-Schmitz, Guzman [1 ,2 ]
Levy, Ofer [1 ,2 ]
机构：
[1] Childrens Hosp Boston, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA 02115 USA
来源：
SCIENCE TRANSLATIONAL MEDICINE | 2011年 / 3卷 / 90期
基金：
比尔及梅琳达.盖茨基金会;
关键词：
ACELLULAR PERTUSSIS-VACCINE; IFN-GAMMA PRODUCTION; T-CELL RESPONSES; INNATE IMMUNITY; POLIOVIRUS VACCINE; BASIC MECHANISMS; CLINICAL-TRIAL; IMMUNIZATION; BIRTH; ADJUVANTS;
D O I：
10.1126/scitranslmed.3001880
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Vaccines for early-life immunization are a crucial biomedical intervention to reduce global morbidity and mortality, yet their developmental path has been largely ad hoc, empiric, and inconsistent. Immune responses of human newborns and infants are distinct and cannot be predicted from those of human adults or animal models. Therefore, understanding and modeling age-specific human immune responses will be vital to the rational design and development of safe and effective vaccines for newborns and infants.
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页数：8
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