Two-week, but not 1-week, hypoxic exposure enhances nitric oxide-mediated basal tone regulation in rat resistance pulmonary arteries

被引:0
作者
Shirai, M
Shimouchi, A
Ikeda, S
Oya, H
Min, KY
Kawaguchi, AT
Mori, H
Ninomiya, I
机构
[1] Natl Cardiovasc Ctr, Res Inst, Dept Cardiac Physiol, Suita, Osaka 5658565, Japan
[2] Osaka Med Coll, Dept Internal Med 1, Osaka 5698686, Japan
[3] Hiroshima Univ, Fac Hlth Sci, Dept Engn, Hiroshima 7240695, Japan
关键词
chronic hypoxia; nitric oxide; basal pulmonary vascular tone;
D O I
10.2170/jjphysiol.51.395
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We measured internal diameter (ID) changes in resistance and conduit pulmonary arteries of 1- and 2-week hypoxic rats and normoxic control rats in response to nitric oxide synthase (NOS) inhibitors in vivo. At 2 weeks of hypoxic exposure, the ID reduction as a result of NOS inhibition was enhanced within the resistance arteries, but not at 1 week of hypoxia.
引用
收藏
页码:395 / 398
页数:4
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