Two-week, but not 1-week, hypoxic exposure enhances nitric oxide-mediated basal tone regulation in rat resistance pulmonary arteries

被引：0
作者：
Shirai, M
Shimouchi, A
Ikeda, S
Oya, H
Min, KY
Kawaguchi, AT
Mori, H
Ninomiya, I
机构：
[1] Natl Cardiovasc Ctr, Res Inst, Dept Cardiac Physiol, Suita, Osaka 5658565, Japan
[2] Osaka Med Coll, Dept Internal Med 1, Osaka 5698686, Japan
[3] Hiroshima Univ, Fac Hlth Sci, Dept Engn, Hiroshima 7240695, Japan
来源：
JAPANESE JOURNAL OF PHYSIOLOGY | 2001年 / 51卷 / 03期
关键词：
chronic hypoxia; nitric oxide; basal pulmonary vascular tone;
D O I：
10.2170/jjphysiol.51.395
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
We measured internal diameter (ID) changes in resistance and conduit pulmonary arteries of 1- and 2-week hypoxic rats and normoxic control rats in response to nitric oxide synthase (NOS) inhibitors in vivo. At 2 weeks of hypoxic exposure, the ID reduction as a result of NOS inhibition was enhanced within the resistance arteries, but not at 1 week of hypoxia.
引用
收藏
页码：395 / 398
页数：4
相关论文
共 20 条
  • [1] BARER G, 1993, J PHYSIOL-LONDON, V463, P1
  • [2] PRESSURE AND FLOW-DEPENDENT VASCULAR TONE
    BEVAN, JA
    LAHER, I
    [J]. FASEB JOURNAL, 1991, 5 (09) : 2267 - 2273
  • [3] CHRONIC HYPOXIA IMPAIRS SOLUBLE GUANYLYL CYCLASE-MEDIATED PULMONARY ARTERIAL RELAXATION IN THE RAT
    CRAWLEY, DE
    ZHAO, L
    GIEMBYCZ, MA
    LIU, SF
    BARNES, PJ
    WINTER, RJD
    EVANS, TW
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (03): : L325 - L332
  • [4] SYSTEMIC AND REGIONAL HEMODYNAMICS AFTER NITRIC-OXIDE SYNTHASE INHIBITION ROLE OF A NEUROGENIC MECHANISM
    HUANG, M
    LEBLANC, ML
    HESTER, RL
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 267 (01): : R84 - R88
  • [5] INCREASED ENDOTHELIUM-DERIVED NO IN HYPERTENSIVE PULMONARY CIRCULATION OF CHRONICALLY HYPOXIC RATS
    ISAACSON, TC
    HAMPL, V
    WEIR, EK
    NELSON, DP
    ARCHER, SL
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1994, 76 (02) : 933 - 940
  • [6] KAY JM, 1983, AM REV RESPIR DIS, V128, pS53
  • [7] INHIBITION OF ENDOTHELIUM-DERIVED RELAXING FACTOR-DEPENDENT CIRCULATORY CONTROL IN INTACT RATS
    LOEB, AL
    LONGNECKER, DE
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (05): : H1494 - H1500
  • [8] MacLean MR, 1997, J PHARMACOL EXP THER, V283, P619
  • [9] EDRF SUPPRESSES AN UNIDENTIFIED VASOCONSTRICTOR MECHANISM IN HYPERTENSIVE RAT LUNGS
    OKA, M
    HASUNUMA, K
    WEBB, SA
    STELZNER, TJ
    RODMAN, DM
    MCMURTRY, IF
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (06): : L587 - L597
  • [10] Chronic inhaled nitric oxide: Effects on pulmonary vascular endothelial function and pathology in rats
    Roos, CM
    Frank, DU
    Xue, C
    Johns, RA
    Rich, GF
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1996, 80 (01) : 252 - 260
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