A facile synthesis of telisatin a via microwave-promoted annulation and Reformatsky reaction

被引：5

作者：

Thasana, Nopporn ^{[1
]}

Bjerke-Kroll, Ben ^{[1
]}

Ruchirawat, Somsak ^{[1
,2
]}

机构：

[1] Chulabhorn Grad Inst, Med Chem Lab, Bangkok 10210, Thailand

[2] Mahidol Univ, Inst Sci & Technol Res & Dev, Programme Res & Dev Synthet Drugs, Nakhon Pathom 73710, Thailand

来源：

SYNLETT | 2008年 / 04期

关键词：

microwave; annulation; Reformatsky reaction; dioxopyrrolo[2,1-a]isoquinoline; dioxoaporphine;

D O I：

10.1055/s-2008-1042764

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile one-pot synthesis of 2,3-dioxopyrrolo[2,1-a]isoquinolines is reported involving the ring formation of aryl pyruvate derivatives with 3,4-dihydroisoquinolines under basic conditions and utilizing the Reformatsky reaction. Using microwave irradiation, the required compounds were obtained in moderate to good yields.

引用

页码：505 / 508

页数：4

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