Papuamides E and F, cytotoxic depsipeptides from the marine sponge Melophlus sp.

被引：27

作者：

Prasad, Pritesh ^{[1
]}

Aalbersberg, William ^{[1
]}

Feussner, Klaus-D. ^{[1
]}

Van Wagoner, Ryan M. ^{[2
]}

机构：

[1] Univ S Pacific, Fac Sci Technol & Environm, Inst Appl Sci, Suva, Fiji

[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

来源：

TETRAHEDRON | 2011年 / 67卷 / 44期

关键词：

Papuamide; Melophlus; Depsipeptide; Cytotoxic; NEW-GUINEA; A-D; SARASSINORUM; MIRABILIS; SAPONINS;

D O I：

10.1016/j.tet.2011.08.100

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two known papuamides C (1) and D (2) together with two new depsipeptides, papuamides E (3) and F (4), were isolated from an undescribed sponge of the genus Melophlus collected in the Solomon Islands. The planar structures of the compounds were elucidated on the basis of spectroscopic studies. Papuamides C-F (1-4) showed cytotoxicity against brine shrimp with LD(50) values between 92 and 106 mu g/mL. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：8529 / 8531

页数：3

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