Papuamides E and F, cytotoxic depsipeptides from the marine sponge Melophlus sp.

被引：27
|
作者：
Prasad, Pritesh [1 ]
Aalbersberg, William [1 ]
Feussner, Klaus-D. [1 ]
Van Wagoner, Ryan M. [2 ]
机构：
[1] Univ S Pacific, Fac Sci Technol & Environm, Inst Appl Sci, Suva, Fiji
[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA
来源：
TETRAHEDRON | 2011年 / 67卷 / 44期
关键词：
Papuamide; Melophlus; Depsipeptide; Cytotoxic; NEW-GUINEA; A-D; SARASSINORUM; MIRABILIS; SAPONINS;
D O I：
10.1016/j.tet.2011.08.100
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two known papuamides C (1) and D (2) together with two new depsipeptides, papuamides E (3) and F (4), were isolated from an undescribed sponge of the genus Melophlus collected in the Solomon Islands. The planar structures of the compounds were elucidated on the basis of spectroscopic studies. Papuamides C-F (1-4) showed cytotoxicity against brine shrimp with LD(50) values between 92 and 106 mu g/mL. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8529 / 8531
页数：3
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