Pulcherrins D-R, potential anti-inflammatory diterpenoids from the roots of Caesalpinia pulcherrima

被引：46

作者：

Yodsaoue, Orapun ^{[1
]}

Karalai, Chatchanok ^{[1
]}

Ponglimanont, Chanita ^{[1
]}

Tewtrakul, Supinya ^{[2
]}

Chantrapromma, Suchada ^{[1
]}

机构：

[1] Prince Songkla Univ, Fac Sci, Dept Chem, Hat Yai 90112, Songkhla, Thailand

[2] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Pharmaceut Bot, Hat Yai 90112, Songkhla, Thailand

来源：

TETRAHEDRON | 2011年 / 67卷 / 36期

关键词：

Caesalpinia pulcherrima; Anti-inflammatory; Cassane-type diterpenes; Pulcherrins D-R; CASSANE DITERPENOIDS;

D O I：

10.1016/j.tet.2011.06.087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioactivity-guided isolation and purification of the dichloromethane extract from the roots of Caesalpinia pulcherrima yielded 15 new cassane-type diterpenes, named pulcherrins D-R (1-15) together with eight known compounds. The structures of the new metabolites were determined on the basis of spectroscopic analyses including 10- and 2D-NMR and mass spectroscopy. The anti-inflammatory activity of isolated compounds was investigated with the lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cell lines. Compounds 8, 9, 11-15, and 17-23 showed potent NO inhibitory activity. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：6838 / 6846

页数：9

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