Pulcherrins D-R, potential anti-inflammatory diterpenoids from the roots of Caesalpinia pulcherrima

被引：46

作者：

Yodsaoue, Orapun ^{[1
]}

Karalai, Chatchanok ^{[1
]}

Ponglimanont, Chanita ^{[1
]}

Tewtrakul, Supinya ^{[2
]}

Chantrapromma, Suchada ^{[1
]}

机构：

[1] Prince Songkla Univ, Fac Sci, Dept Chem, Hat Yai 90112, Songkhla, Thailand

[2] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Pharmaceut Bot, Hat Yai 90112, Songkhla, Thailand

来源：

TETRAHEDRON | 2011年 / 67卷 / 36期

关键词：

Caesalpinia pulcherrima; Anti-inflammatory; Cassane-type diterpenes; Pulcherrins D-R; CASSANE DITERPENOIDS;

D O I：

10.1016/j.tet.2011.06.087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioactivity-guided isolation and purification of the dichloromethane extract from the roots of Caesalpinia pulcherrima yielded 15 new cassane-type diterpenes, named pulcherrins D-R (1-15) together with eight known compounds. The structures of the new metabolites were determined on the basis of spectroscopic analyses including 10- and 2D-NMR and mass spectroscopy. The anti-inflammatory activity of isolated compounds was investigated with the lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cell lines. Compounds 8, 9, 11-15, and 17-23 showed potent NO inhibitory activity. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：6838 / 6846

页数：9

共 15 条

[1]

Banskota AH, 2003, PLANTA MED, V69, P500, DOI 10.1055/s-2003-40641

[2] PULCHERRALPIN, A NEW DITERPENE ESTER FROM CAESALPINIA-PULCHERRIMA [J].

CHE, CT ;

MCPHERSON, DD ;

CORDELL, GA ;

FONG, HHS .

JOURNAL OF NATURAL PRODUCTS, 1986, 49 (04) :561-569

[3] New diterpenoids from stems and roots of Caesalpinia crista [J].

Cheenpracha, S ;

Srisuwan, R ;

Karalai, C ;

Ponglimanont, C ;

Chantrapromma, S ;

Chantrapromma, K ;

Fun, HK ;

Anjum, S ;

Atta-ur-Rahman .

TETRAHEDRON, 2005, 61 (36) :8656-8662

[4] THE APPLICATION OF VACUUM LIQUID-CHROMATOGRAPHY TO THE SEPARATION OF TERPENE MIXTURES [J].

COLL, JC ;

BOWDEN, BF .

JOURNAL OF NATURAL PRODUCTS, 1986, 49 (05) :934-936

[5] New diterpenoids from Caesalpinia species and their cytotoxic activity [J].

Das, Biswanath ;

Srinivas, Yallamalla ;

Sudhakar, Chithaluri ;

Mahender, Ibram ;

Laxminarayana, Keetha ;

Reddy, Parigi Raghavendar ;

Raju, Tuniki Venugopal ;

Jakka, Naga Mahesh ;

Rao, Janapala Venkateswara .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (09) :2847-2850

[6] Ehrlich's reaction of furanoeremophilanes [J].

Kuroda, C ;

Ueshino, T ;

Nagano, H .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2004, 77 (09) :1737-1740

[7] DITERPENOIDS FROM CAESALPINIA-PULCHERRIMA [J].

MCPHERSON, DD ;

CHE, CT ;

CORDELL, GA ;

SOFIARTO, DD ;

PEZZUTO, JM ;

FONG, HHS .

PHYTOCHEMISTRY, 1985, 25 (01) :167-170

[8] Pulcherrimins A-D, novel diterpene dibenzoates from Caesalpinia pulcherrima with selective activity against DNA repair-deficient yeast mutants [J].

Patil, AD ;

Freyer, AJ ;

Webb, RL ;

Zuber, G ;

Reichwein, R ;

Bean, MF ;

Faucette, L ;

Johnson, RK .

TETRAHEDRON, 1997, 53 (05) :1583-1592

[9] Cassane diterpenoids from the stem of Caesalpinia pulcherrima [J].

Pranithanchai, Wirote ;

Karalai, Chatchanok ;

Ponglimanont, Chanita ;

Subhadhirasakul, Sanan ;

Chantrapromma, Kan .

PHYTOCHEMISTRY, 2009, 70 (02) :300-304

[10]

Promsawan N, 2003, PLANTA MED, V69, P776, DOI 10.1055/s-2003-42782

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