Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures

被引：3

作者：

Gore, Sangram ^{[1
,2
]}

Baskaran, Sundarababu ^{[1
]}

Koenig, Burkhard ^{[2
]}

机构：

[1] Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India

[2] Univ Regensburg, Inst Organ Chem, Univ Str 31, D-93040 Regensburg, Germany

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 18卷

关键词：

green protocol; mild conditions; no additional catalyst; solvent free; triple role of melt; CALCIUM-CHANNEL BLOCKERS; UREA-SALT MIXTURES; ACID-ESTERS; CYCLOCONDENSATION REACTION; POTENT MIMICS; SOLVENTS; ANTAGONISTS; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; DERIVATIVES; INHIBITOR;

D O I：

10.3762/bjoc.18.37

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from beta,gamma-unsaturated ketoesters in low melting L-(+)-tartaric acid-N,N-dimethylurea mixtures is reported. This solvent-free method is very general and provides easy access to 5-unsubstituted dihydropyrimidinone-4-carboxylate derivatives in good yields.

引用

页码：331 / 336

页数：6

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