Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures

被引：2

作者：

Gore, Sangram ^{[1
,2
]}

Baskaran, Sundarababu ^{[1
]}

Koenig, Burkhard ^{[2
]}

机构：

[1] Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India

[2] Univ Regensburg, Inst Organ Chem, Univ Str 31, D-93040 Regensburg, Germany

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 18卷

关键词：

green protocol; mild conditions; no additional catalyst; solvent free; triple role of melt; CALCIUM-CHANNEL BLOCKERS; UREA-SALT MIXTURES; ACID-ESTERS; CYCLOCONDENSATION REACTION; POTENT MIMICS; SOLVENTS; ANTAGONISTS; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; DERIVATIVES; INHIBITOR;

D O I：

10.3762/bjoc.18.37

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from beta,gamma-unsaturated ketoesters in low melting L-(+)-tartaric acid-N,N-dimethylurea mixtures is reported. This solvent-free method is very general and provides easy access to 5-unsubstituted dihydropyrimidinone-4-carboxylate derivatives in good yields.

引用

页码：331 / 336

页数：6

共 50 条

[21] Regioselective synthesis of 3,4-diaryl-5-unsubstituted isoxazoles, analogues of natural cytostatic combretastatin A4
Chernysheva, Natalia B.
Maksimenko, Anna S.
Andreyanov, Fedor A.
Kislyi, Victor P.
Strelenko, Yuri A.
Khrustalev, Victor N.
Semenova, Marina N.
Semenov, Victor V.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 146 : 511 - 518
[22] Production of 5-Hydroxymethyl-2-furan Carboxylic Acid Using Biobased Silver Nanoparticles in Deep Eutectic Substrate Reaction Mixtures
Kargar, Pouya Ghamari
Sadughi, Mohammad Mehdi
Bahadoran, Ashkan
Zabibah, Rahman S.
Len, Christophe
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2023, 11 (45) : 16030 - 16041
[23] Synthesis and antitumor evaluation of hybrids of 5,8-dioxo-5,8-dihydroisoquinoline4-carboxylates and carbohydrates
da Silva, Wanderson A.
da Silva, Luiz C. R. P.
Campos, Vinicius R.
de Souza, Maria C. B. V.
Ferreira, Vitor F.
dos Santos, Angela C. P. B.
Sathler, Plinio C.
de Almeida, Gabriella S.
Dias, Flaviana R. F.
Cabral, Lucio M.
de Azeredo, Rodrigo B. V.
Cunha, Anna C.
FUTURE MEDICINAL CHEMISTRY, 2018, 10 (05) : 527 - 540
[24] Meglumine-based Sustainable Three-component Deep Eutectic Solvent Applicable for the Synthesis of Pyrazolo[5,1-b]quinazoline-3-carboxylates as a Sensing Probe for Cu2+ Ions
Parekh, Jaydeepkumar N.
Patel, Manan S.
Chudasama, Dipakkumar D.
Patel, Harsh C.
Sutariya, Pinkesh G.
Soni, Heni N.
Rajput, Chetan V.
Ram, Kesur R.
CHEMISTRY-AN ASIAN JOURNAL, 2024, 19 (06)
[25] Synthesis and reactivity of methyl 3-acyl-6-amino-4-aryl-5-cyano-4H-pyran-2-carboxylates
Sheverdov, V. P.
Andreev, A. Yu.
Ershov, O. V.
Nasakin, O. E.
Tafeenko, V. A.
Gein, V. L.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2012, 48 (07) : 997 - 1005
[26] Synthesis and Structure of Methyl 6-Aryl-5-aroyl-4-hydroxy2-oxo(thioxo)hexahydropyrimidine-4-carboxylates
Gein, V. L.
Zamaraeva, T. M.
Gorgopina, E. V.
Dmitriev, M. V.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2022, 92 (10) : 1894 - 1898
[27] Green Synthesis of 2-thioxothiazolidin-4-one Derivatives in Deep Eutectic Solvents via Knoevenagel Condensation
Loncaric, Melita
Molnar, Maja
LETTERS IN ORGANIC CHEMISTRY, 2022, 19 (10) : 890 - 901
[28] Diastereoselective multicomponent synthesis of (4RS,6SR)-4,6-diaryl-5,5-dicyano-2-methyl-1,4,5,6-tetrahydropyridine-3-carboxylates
Vereshchagin, A. N.
Karpenko, K. A.
Iliyasov, T. M.
Elinson, M. N.
Dorofeeva, E. O.
Fakhrutdinov, A. N.
Egorov, M. P.
RUSSIAN CHEMICAL BULLETIN, 2018, 67 (11) : 2049 - 2053
[29] Solvent-Free Synthesis of α-Cyanophosphonates from β-Nitrostyrenes by Using a Deep-Eutectic Solvent Catalyst
Shamsaddinimotlagh, Sima
Ranjbari, Mohammad A.
Tavakol, Hossein
Shi, Min
SYNLETT, 2024, 35 (15) : 1822 - 1827
[30] Synthesis of Diarylethynes from Aryldiazonium Salts by Using Calcium Carbide as an Alkyne Source in a Deep Eutectic Solvent
Ma, Xiaolong
Li, Zheng
SYNLETT, 2021, 32 (06) : 631 - 635

← 1 2 3 4 5 →