Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures

被引：2
|
作者：
Gore, Sangram [1 ,2 ]
Baskaran, Sundarababu [1 ]
Koenig, Burkhard [2 ]
机构：
[1] Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India
[2] Univ Regensburg, Inst Organ Chem, Univ Str 31, D-93040 Regensburg, Germany
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 18卷
关键词：
green protocol; mild conditions; no additional catalyst; solvent free; triple role of melt; CALCIUM-CHANNEL BLOCKERS; UREA-SALT MIXTURES; ACID-ESTERS; CYCLOCONDENSATION REACTION; POTENT MIMICS; SOLVENTS; ANTAGONISTS; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; DERIVATIVES; INHIBITOR;
D O I：
10.3762/bjoc.18.37
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from beta,gamma-unsaturated ketoesters in low melting L-(+)-tartaric acid-N,N-dimethylurea mixtures is reported. This solvent-free method is very general and provides easy access to 5-unsubstituted dihydropyrimidinone-4-carboxylate derivatives in good yields.
引用
收藏
页码：331 / 336
页数：6
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