Adult-Onset Still's Disease: A Case Report and Review of Current Therapeutic Options

被引：2

作者：

Thomas, Steffi ^{[1
]}

Kesarwani, Vartika ^{[2
]}

Graber, Melanie ^{[3
]}

Joshi, Weishali ^{[4
]}

机构：

[1] Univ Connecticut, Dept Rheumatol, Farmington, CT USA

[2] Univ Connecticut, Dept Internal Med, Farmington, CT 06030 USA

[3] Univ Connecticut Hlth, Dept Rheumatol, Farmington, CT USA

[4] St Francis Hosp & Med Ctr, Dept Rheumatol, Hartford, CT USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 03期

关键词：

treatment; still's disease; interleukin-6; inhibitors; tocilizumab; adult-onset still's disease; BIOLOGIC AGENTS; SERUM FERRITIN; MULTICENTER; CLASSIFICATION; TOCILIZUMAB; ARTHRITIS; EFFICACY; ANAKINRA; CRITERIA;

D O I：

10.7759/cureus.22743

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adult-onset Still's disease (AOSD) is a rare autoinflammatory disease that typically presents with a triad of fever, evanescent rash, and arthritis. There is often a delay in diagnosis of AOSD due to its nonspecific clinical presentation, which may mimic other infectious, rheumatological disorders, and malignancies. Corticosteroids have been the cornerstone for the management of AOSD for the past many years. However, with the expanding understanding of its pathogenesis, novel therapeutic options targeting various cytokines are being increasingly recognized. Herein, we present a case of AOSD that was successfully treated with tocilizumab, a monoclonal antibody against the interleukin-6 (IL-6) receptor. For the purpose of this article, we also conducted a literature search to review the current therapeutic options available for the treatment of AOSD.

引用

页数：6

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