Stem cell trafficking in tissue development, growth, and disease

被引：258
作者：
Laird, Diana J. [2 ]
von Andrian, Ulrich H. [3 ]
Wagers, Amy J. [1 ,4 ,5 ]
机构：
[1] Joslin Diabet Ctr, Boston, MA 02215 USA
[2] Mem Sloan Kettering Canc Ctr, Dev Biol Program, New York, NY 10058 USA
[3] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[4] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA
[5] Harvard Univ, Stem Cell Inst, Cambridge, MA 02138 USA
来源：
CELL | 2008年 / 132卷 / 04期
关键词：
D O I：
10.1016/j.cell.2008.01.041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Regulated movement of stem cells is critical for organogenesis during development and for homeostasis and repair in adulthood. Here we analyze the biological significance and molecular mechanisms underlying stem cell trafficking in the generation of the germline, and the generation and regeneration of blood and muscle. Comparison across organisms and lineages reveals remarkable conservation as well as specialization in homing and migration mechanisms used by mature leukocytes, adult and fetal stem cells, and cancer stem cells. In vivo trafficking underpins the successful therapeutic application of hematopoietic stem cells for bone-marrow transplant, and further elucidation of homing and migration pathways in other systems will enable broader application of stem cells for targeted cell therapy and drug delivery.
引用
收藏
页码：612 / 630
页数：19
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