Stem cell trafficking in tissue development, growth, and disease

被引：259

作者：

Laird, Diana J. ^{[2
]}

von Andrian, Ulrich H. ^{[3
]}

Wagers, Amy J. ^{[1
,4
,5
]}

机构：

[1] Joslin Diabet Ctr, Boston, MA 02215 USA

[2] Mem Sloan Kettering Canc Ctr, Dev Biol Program, New York, NY 10058 USA

[3] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[4] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

[5] Harvard Univ, Stem Cell Inst, Cambridge, MA 02138 USA

来源：

CELL | 2008年 / 132卷 / 04期

关键词：

D O I：

10.1016/j.cell.2008.01.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulated movement of stem cells is critical for organogenesis during development and for homeostasis and repair in adulthood. Here we analyze the biological significance and molecular mechanisms underlying stem cell trafficking in the generation of the germline, and the generation and regeneration of blood and muscle. Comparison across organisms and lineages reveals remarkable conservation as well as specialization in homing and migration mechanisms used by mature leukocytes, adult and fetal stem cells, and cancer stem cells. In vivo trafficking underpins the successful therapeutic application of hematopoietic stem cells for bone-marrow transplant, and further elucidation of homing and migration pathways in other systems will enable broader application of stem cells for targeted cell therapy and drug delivery.

引用

页码：612 / 630

页数：19

共 143 条

[1] Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure [J].

Abkowitz, JL ;

Robinson, AE ;

Kale, S ;

Long, MW ;

Chen, J .

BLOOD, 2003, 102 (04) :1249-1253

[2] Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor [J].

Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States ;

不详 ;

不详 .

Nature, 2006, 7076 (599-603) :599-603

[3]

ALADHAMI MA, 1977, DEV GROWTH DIFFER, V19, P171, DOI 10.1111/j.1440-169X.1977.00171.x

[4]

Anderson R, 1999, DEVELOPMENT, V126, P1655

[5] The onset of germ cell migration in the mouse embryo [J].

Anderson, R ;

Copeland, TK ;

Schöler, H ;

Heasman, J ;

Wylie, C .

MECHANISMS OF DEVELOPMENT, 2000, 91 (1-2) :61-68

[6] Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1) [J].

Ara, T ;

Nakamura, Y ;

Egawa, T ;

Sugiyama, T ;

Abe, K ;

Kishimoto, T ;

Matsui, Y ;

Nagasawa, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :5319-5323

[7] Integrin α6β1-laminin interactions regulate early myotome formation in the mouse embryo [J].

Bajanca, F ;

Luz, M ;

Raymond, K ;

Martins, GG ;

Sonnenberg, A ;

Tajbakhsh, S ;

Buckingham, M ;

Thorsteinsdóttir, S .

DEVELOPMENT, 2006, 133 (09) :1635-1644

[8] Cancer and the chemokine network [J].

Balkwill, F .

NATURE REVIEWS CANCER, 2004, 4 (07) :540-550

[9] The role of cadherins during primordial germ cell migration and early gonad formation in the mouse [J].

Bendel-Stenzel, MR ;

Gomperts, M ;

Anderson, R ;

Heasman, J ;

Wylie, C .

MECHANISMS OF DEVELOPMENT, 2000, 91 (1-2) :143-152

[10]

BERNSTEIN A, 1991, SEMIN HEMATOL, V28, P138

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