Gami-Chunghyuldan ameliorates memory impairment and neurodegeneration induced by intrahippocampal Aβ1-42 oligomer injection

被引：23

作者：

Choi, Jin Gyu ^{[1
,2
]}

Moon, Minho ^{[3
]}

Kim, Hyo Geun ^{[1
,2
]}

Mook-Jung, Inhee ^{[3
]}

Chung, Sun Yong ^{[4
]}

Kang, Tong Ho ^{[5
]}

Kim, Sun Yeou ^{[6
]}

Lee, Eunjoo H. ^{[6
]}

Oh, Myung Sook ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Coll Pharm, Dept Oriental Pharmaceut Sci, Seoul 130701, South Korea

[2] Kyung Hee Univ, Kyung Hee EW Pharmaceut Res Inst, Seoul 130701, South Korea

[3] Seoul Natl Univ, Coll Med, Dept Biochem, Seoul 110799, South Korea

[4] Kyung Hee Neo Med Ctr, Dept Oriental Neuropsychiat, Seoul 134727, South Korea

[5] Kyung Hee Univ, Coll Life Sci, Dept Oriental Med Mat & Proc, Yongin 446701, Gyeonggi Do, South Korea

[6] Kyung Hee Univ, Dept Med Sci, Grad Sch EW Med Sci, Yongin 446701, Gyeonggi Do, South Korea

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2011年 / 96卷 / 02期

关键词：

Gami-Chunghyuldan; Alzheimer's disease; Amyloid beta oligomer; Memory impairment; Neurodegeneration; AMYLOID-BETA-PROTEIN; LONG-TERM POTENTIATION; CENTRAL-NERVOUS-SYSTEM; ALZHEIMERS-DISEASE; A-BETA; CELL-DEATH; INFLAMMATORY RESPONSE; MULTIFUNCTIONAL DRUGS; SYNAPTIC-TRANSMISSION; TRANSGENIC MICE;

D O I：

10.1016/j.nlm.2011.06.004

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Soluble oligomeric forms of amyloid beta (A beta O) are regarded as a main cause of synaptic and cognitive dysfunction in Alzheimer's disease (AD) and have been a primary target in the development of drug treatments for AD. The present study utilized a mouse model of AD induced by intrahippocampal injection of A beta O (10 mu M) to investigate the effects of Gami-Chunghyuldan (GCD), a standardized multi-herbal medicinal formula, on the presentation of memory deficits and neurohistological pathogenesis. GCD (10 and 50 mg/kg/day, 5 days, p.o.) improved A beta O-induced memory impairment as well as reduced neuronal cell death, astrogliosis, and microgliosis in the hippocampus. In addition, GCD prevented A beta O-triggered synaptic disruption and cholinergic fiber loss. These results suggest that GCD may be useful in the prevention and treatment of AD. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：306 / 314

页数：9

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