Association of IL1R1 gene (SNP rs2071374) with the risk of preeclampsia

被引：7
作者：
Sivaraj, Nagarjuna [1 ]
Rachel, K., V [1 ]
Suvvari, Tarun Kumar [2 ]
Prasad, Shilaja [3 ]
Boppana, Sri Harsha [4 ]
Vegi, Pradeep Kumar [5 ]
机构：
[1] GITAM Deemed Univ, Dept Biochem & Bioinformat, Visakhapatnam, Andhra Pradesh, India
[2] Dr NTR Univ Hlth Sci, Visakhapatnam, Andhra Pradesh, India
[3] Great Eastern Med Sch & Hosp, Dept Obstet & Gynecol, Ragolu, Srikakularn, India
[4] Great Eastern Med Sch & Hosp, Ragolu, Srikakulam, India
[5] Great Eastern Med Sch & Hosp, Dept Biochem, Ragolu, Srikakulam, India
来源：
JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2022年 / 149卷
关键词：
Interleukin; Preeclampsia; SNP; Pregnancy; Inflammation; POLYMORPHISMS; INTERLEUKIN-1; INHIBITION; ECLAMPSIA; MEDIATOR;
D O I：
10.1016/j.jri.2021.103463
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background: Association of IL1R1rs2071374 with the risk of preeclampsia compared with normotensive pregnant women. Methodology: The study was a case-control study with 304 pregnant women comprising of preeclampsia (n = 152) and normotensive pregnancies (n = 152). And SNP rs2071374 was genotyped by PCR-RFLP method. Results: The presence of IL1R1rs2071374G allele was associated with the increased risk of preeclampsia P = 0.01741, odds ratio = 0.7006 (95% CI: 0.5023-0.9759). Conclusion: The results indicated that there was an association in IL1R1 rs2071374SNP with preeclampsia compared to non-preeclampsia women. It is the first study to evaluate that IL1R1 polymorphism is correlated with preeclampsia pathogenesis in the Population in India.
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页数：4
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共 28 条
  • [1] ACOG Committee on Obstetric Practice, 2002, Int J Gynaecol Obstet, V77, P67
  • [2] The Feto-Maternal Outcome of Preeclampsia with Severe Features and Eclampsia in Abakaliki, South-East Nigeria
    Ajah, Leonard Ogbonna
    Ozonu, Nelson Chukwudi
    Ezeonu, Paul Olisaemeka
    Lawani, Lucky Osaheni
    Obuna, Johnson Akuma
    Onwe, Emeka Ogah
    [J]. JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016, 10 (09) : QC18 - QC21
  • [3] Polymorphisms in the inflammatory pathway genes and the risk of preeclampsia in Sinhalese women
    Andraweera, Prabha H.
    Dekker, Gustaaf A.
    Jayasekara, Rohan W.
    Dissanayake, Vajira H. W.
    Roberts, Claire T.
    [J]. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2016, 29 (07) : 1072 - 1076
  • [4] INTERLEUKIN-1 RECEPTOR ANTAGONIST - A NEW MEMBER OF THE INTERLEUKIN-1 FAMILY
    AREND, WP
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (05) : 1445 - 1451
  • [5] IL-1α/IL-1R1 Expression in Chronic Obstructive Pulmonary Disease and Mechanistic Relevance to Smoke-Induced Neutrophilia in Mice
    Botelho, Fernando M.
    Bauer, Carla M. T.
    Finch, Donna
    Nikota, Jake K.
    Zavitz, Caleb C. J.
    Kelly, Ashling
    Lambert, Kristen N.
    Piper, Sian
    Foster, Martyn L.
    Goldring, James J. P.
    Wedzicha, Jadwiga A.
    Bassett, Jennifer
    Bramson, Jonathan
    Iwakura, Yoichiro
    Sleeman, Matthew
    Kolbeck, Roland
    Coyle, Anthony J.
    Humbles, Alison A.
    Staempfli, Martin R.
    [J]. PLOS ONE, 2011, 6 (12):
  • [6] The Global Impact of Pre-eclampsia and Eclampsia
    Duley, Lelia
    [J]. SEMINARS IN PERINATOLOGY, 2009, 33 (03) : 130 - 137
  • [7] Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes
    Everett, Brendan M.
    Donath, Marc Y.
    Pradhan, Aruna D.
    Thuren, Tom
    Pais, Prem
    Nicolau, Jose C.
    Glynn, Robert J.
    Libby, Peter
    Ridker, Paul M.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018, 71 (21) : 2392 - 2401
  • [8] Inflammatory Mediators Gene Polymorphisms in Preeclampsia
    Franchim, Camila S.
    Sass, Nelson
    Mattar, Rosiane
    Pendeloski, Karen P. T.
    Lin, Lawrence Hsu
    Torloni, Maria R.
    Daher, Silvia
    [J]. HYPERTENSION IN PREGNANCY, 2011, 30 (03) : 338 - 346
  • [9] Interleukin-1 alpha variation is associated with the risk of developing preeclampsia
    Ghasemi, Masoumeh
    Kashani, Elham
    Fayyaz, Azadeh
    Attar, Marzieh
    Shahbazi, Majid
    [J]. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2015, 193 : 75 - 78
  • [10] Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes
    Goddard, Katrina A. B.
    Tromp, Gerard
    Romero, Roberto
    Olson, Jane M.
    Lu, Qing
    Xu, Zhiying
    Parimi, Neeta
    Nien, Jyh Kae
    Gomez, Ricardo
    Behnke, Ernesto
    Solari, Margarita
    Espinoza, Jimmy
    Santolaya, Joaquin
    Chaiworapongsa, Tinnakorn
    Lenk, Guy M.
    Volkenant, Kimberly
    Anant, Madan Kumar
    Salisbury, Benjamin A.
    Carr, Janet
    Lee, Min Soeb
    Vovis, Gerald F.
    Kuivaniemi, Helena
    [J]. HUMAN HEREDITY, 2007, 63 (01) : 1 - 16
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