Iodine-Mediated Oxidative Annulation by C-C Cleavage: A Domino Synthetic Approach to Quinazolinones and Benzo[4,5]imidazo[1,2-c]quinazolines

被引：5
作者：
Donthiboina, Kavitha [1 ]
Mani, Geeta Sai [1 ]
Shankaraiah, Nagula [1 ]
Kamal, Ahmed [1 ,2 ]
机构：
[1] NIPER Hyderabad, Dept Med Chem, Hyderabad 500037, Andhra Pradesh, India
[2] Jamia Hamdard, SPER, New Delhi 110062, India
来源：
CHEMISTRYSELECT | 2020年 / 5卷 / 13期
关键词：
Annulation; Benzimidazo-quinazolines; C-C bond cleavage; Cleavage reactions; Copper iodide; Domino process; I-2; Quinazolinones; ONE-POT SYNTHESIS; CARBON BOND-CLEAVAGE; CONTAINING HETEROCYCLES; O-AMINOBENZAMIDES; N-HETEROCYCLES; ACTIVATION; CHEMISTRY; CONSTRUCTION; AMINES; QUINAZOLIN-4(3H)-ONES;
D O I：
10.1002/slct.202000682
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile iodine-mediated unprecedented C-C cleavage by employing CuI has been established towards the synthesis of quinazolin-4(3H)-ones and benzo[4,5]imidazo[1,2-c]quinazolines. This protocol involves peroxide free synthetic approach for the stable C-C bond cleavage followed by oxidative annulation to develop a library of fused N-heterocyclic molecules.
引用
收藏
页码：3923 / 3928
页数：6
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