Isolation and characterization of two new drimanes from Zygogynum baillonii and synthesis of analogues

被引:14
作者
Fotsop, Dalia Fornekong [1 ]
Roussi, Fanny [1 ]
Le Callonec, Catherine [1 ]
Bousserouel, Hadjira [1 ]
Litaudon, Marc [1 ]
Gueritte, Francoise [1 ]
机构
[1] CNRS, Inst Chim Subst Nat, UPR 2301, F-91198 Gif Sur Yvette, France
关键词
SACCHAROMYCES-CEREVISIAE; DERIVATIVES;
D O I
10.1016/j.tet.2007.12.022
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Two new drimanes were isolated and characterized from the bark of Zygogynum baillonii, an endemic New-Caledonian tree of the Winter-aceae family. One of it shows a significant cytotoxic activity. In order to define structure-activity relationships, analogues were synthesized and their cytotoxicity was evaluated. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2192 / 2197
页数:6
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