Scavenging ability on ROS of alpha-lipoic acid (ALA)

被引：24

作者：

Li, Y ^{[1
]}

Zhao, YP ^{[1
]}

Yu, WL ^{[1
]}

Jiang, SY ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Technol, Shanghai 200240, Peoples R China

来源：

FOOD CHEMISTRY | 2004年 / 84卷 / 04期

关键词：

alpha-lipoic acid; reactive oxygen species; superoxide anions; hydroxyl radical; hydrogen peroxide; chemiluminescence;

D O I：

10.1016/S0308-8146(03)00279-6

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The scavenging ability of alpha-lipoic acid (ALA) towards superoxide anions, hydroxyl radicals and hydrogen peroxide was evaluated by means of chemiluminescence (CL). In neutral or acid conditions, ALA could scavenge superoxide anions and its scavenging efficiency depended on its concentration. In neutral or alkaline conditions, the CL intensity of the reaction of ALA with hydroxyl radical (OH. radicals) decreased after the first 10 min and then increased with time, suggesting that ALA could scavenge OH. radicals at the beginning, but yielded unknown intermediate products that could lead to the increase of CL intensity at later stages. The increase of CL intensity in the reaction of hydrogen peroxide with ALA may also be due to these products. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：563 / 567

页数：5

共 9 条

[1]

DAVID H, 2001, J HEPATOL, V34, P76

[2]

Handler MR, 1999, GEOLOGY, V27, P75, DOI 10.1130/0091-7613(1999)027<0075:EFCIOA>2.3.CO

[3]

[4]

HIROYUKI K, 1998, J CHROMATOGR B, V717, P247

[5]

MARKLUND S, 1974, EUR J BIOCHEM, V47, P469

[6] Alpha lipoic acid (ALA) protects proteins against the hydroxyl free radical-induced alterations:: rationale for its geriatric topical application [J].

Perricone, N ;

Nagy, G ;

Horváth, F ;

Dajkó, G ;

Uray, I ;

Zs-Nagy, I .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 1999, 29 (01) :45-56

[7]

SUDESH V, 2002, NUTR RES, V22, P111

[8]

SUSHIL K, 2000, FREE RADICAL BIO MED, V29, P1122

[9] Antioxidant activity of natural vitamin E extracted from soybean sludge as assessed by chemiluminescence [J].

Yu, WL ;

Zhao, YP ;

Xue, Z ;

Jin, H ;

Wang, DP ;

Liang, XF ;

Hu, TX .

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2002, 82 (02) :230-233

← 1 →