Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical Outcomes

被引：35
作者：
Ramia, Paul [1 ]
Bodgi, Larry [2 ]
Mahmoud, Dima [2 ]
Mohammad, Mohammad A. [2 ]
Youssef, Bassem [2 ]
Kopek, Neil [1 ]
Al-Shamsi, Humaid [3 ,4 ,5 ]
Dagher, Mona [2 ]
Abu-Gheida, Ibrahim [3 ,4 ,6 ]
机构：
[1] McGill Univ, Hlth Ctr, Montreal, PQ, Canada
[2] Amer Univ Beirut, Dept Radiat Oncol, Med Ctr, Beirut, Lebanon
[3] Burjeel Canc Inst, 28th St, Abu Dhabi, U Arab Emirates
[4] Oncol Soc, Dubai, U Arab Emirates
[5] Univ Sharjah, Sharjah, U Arab Emirates
[6] United Arab Emirates Univ, Al Ain, U Arab Emirates
来源：
CLINICAL MEDICINE INSIGHTS-ONCOLOGY | 2022年 / 16卷
关键词：
Radiotherapy; head and neck radiation; fibrosis; prevention; QUALITY-OF-LIFE; DOUBLE-STRAND BREAKS; COMBINED PENTOXIFYLLINE; ORAL COMPLICATIONS; INDUCED TRISMUS; LATE TOXICITY; ATM PROTEIN; THERAPY; RADIOTHERAPY; RADIOSENSITIVITY;
D O I：
10.1177/11795549211036898
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Radiotherapy-related fibrosis remains one of the most challenging treatment related side effects encountered by patients with head and neck cancer. Several established and ongoing novel therapies have been studied with paucity of data in how to best treat these patients. This review aims to provide researchers and health care providers with a comprehensive review on the presentation, etiology, and therapeutic options for this serious condition.
引用
收藏
页数：7
相关论文
共 50 条
[41]   The effectiveness of mouthwashes in alleviating radiation-induced oral mucositis in head and neck cancer patients: a systematic review [J].
Masaru Konishi ;
Rinus Gerardus Verdonschot ;
Kiichi Shimabukuro ;
Takashi Nakamoto ;
Minoru Fujita ;
Naoya Kakimoto .
Oral Radiology, 2019, 35 :207-223
[42]   Botox for the prevention of radiation-induced Sialadenitis and xerostomia in head and neck cancer patients: A pilot study [J].
Nieri, Chad Alexander ;
Benaim, Ezer Haim ;
Zhang, Yanhui H. ;
Garcia-Godoy, Franklin ;
Herr, Michael J. ;
Zhang, Weiqiang ;
Schwartz, David ;
Coca, Kimberly K. ;
Gleysteen, John P. ;
Gillespie, Marion Boyd .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2023, 45 (09) :2198-2206
[43]   Influence of smoking history on the perception of radiation-induced dysgeusia/hypogeusia in patients with head and neck cancer [J].
Park, DaMin ;
Jain, Shruti ;
Quay-De La Vallee, Zachary ;
Huber, Kathryn ;
O'Leary, Miriam ;
Farag, Arwa M. .
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2021, 278 (08) :2993-3001
[44]   Assessment of Radiation-Induced Xerostomia Validation of the Xerostomia Questionnaire in Chinese Patients With Head and Neck Cancer [J].
Jiang, Nan ;
Wei, Siqi ;
Martensson, Jan ;
Zhao, Yue ;
Arestedt, Kristofer .
CANCER NURSING, 2021, 44 (02) :E68-E75
[45]   Polaprezinc reduces the severity of radiation-induced mucositis in head and neck cancer patients [J].
Doi, Hiroshi ;
Fujiwara, Masayuki ;
Suzuki, Hitomi ;
Niwa, Yasue ;
Nakayama, Masahiro ;
Shikata, Toshiyuki ;
Odawara, Soichi ;
Takada, Yasuhiro ;
Kimura, Takeshi ;
Kamikonya, Norihiko ;
Hirota, Shozo .
MOLECULAR AND CLINICAL ONCOLOGY, 2015, 3 (02) :381-386
[46]   Radiation-induced osteosarcoma in the head and neck region: Case report and literature review [J].
Ferreira, Iara Vieira ;
Cattan, Marcelo Elias Schempf ;
Chone, Carlos Takahiro ;
Antolini, Arthur ;
Abu Egal, Erika Said ;
Altemani, Albina ;
Mariano, Fernanda Viviane .
ORAL ONCOLOGY, 2025, 162
[47]   Pravastatin Reverses Established Radiation-Induced Cutaneous and Subcutaneous Fibrosis in Patients With Head and Neck Cancer: Results of the Biology-Driven Phase 2 Clinical Trial Pravacur [J].
Bourgier, Celine ;
Auperin, Anne ;
Rivera, Sofia ;
Boisselier, Pierre ;
Petit, Benoit ;
Lang, Philippe ;
Lassau, Nathalie ;
Taourel, Patrice ;
Tetreau, Raphael ;
Azria, David ;
Bourhis, Jean ;
Deutsch, Eric ;
Vozenin, Marie-Catherine .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2019, 104 (02) :365-373
[48]   Radiation-induced sarcomas of the head and neck [J].
Anuradha Thiagarajan ;
N Gopalakrishna Iyer .
World Journal of Clinical Oncology, 2014, (05) :973-981
[49]   Efficacy of bethanechol chloride in the treatment of radiation-induced xerostomia in patients with head and neck cancer: A systematic review and meta-analysis [J].
Nakamura, Denise Moral ;
da Graca Pinto, Henrique ;
Elchin, Cintia Baena ;
Berard, Lucas Thomazotti ;
Alves, Fabio Abreu ;
Antunes, Livia Azeredo Alves ;
Coto, Neide Pena .
RADIOTHERAPY AND ONCOLOGY, 2023, 186
[50]   Radiation-induced sarcomas of the head and neck [J].
Thiagarajan, Anuradha ;
Iyer, N. Gopalakrishna .
WORLD JOURNAL OF CLINICAL ONCOLOGY, 2014, 5 (05) :973-981
12345