Radiation-Induced Fibrosis in Patients with Head and Neck Cancer: A Review of Pathogenesis and Clinical Outcomes

被引：32
作者：
Ramia, Paul [1 ]
Bodgi, Larry [2 ]
Mahmoud, Dima [2 ]
Mohammad, Mohammad A. [2 ]
Youssef, Bassem [2 ]
Kopek, Neil [1 ]
Al-Shamsi, Humaid [3 ,4 ,5 ]
Dagher, Mona [2 ]
Abu-Gheida, Ibrahim [3 ,4 ,6 ]
机构：
[1] McGill Univ, Hlth Ctr, Montreal, PQ, Canada
[2] Amer Univ Beirut, Dept Radiat Oncol, Med Ctr, Beirut, Lebanon
[3] Burjeel Canc Inst, 28th St, Abu Dhabi, U Arab Emirates
[4] Oncol Soc, Dubai, U Arab Emirates
[5] Univ Sharjah, Sharjah, U Arab Emirates
[6] United Arab Emirates Univ, Al Ain, U Arab Emirates
来源：
CLINICAL MEDICINE INSIGHTS-ONCOLOGY | 2022年 / 16卷
关键词：
Radiotherapy; head and neck radiation; fibrosis; prevention; QUALITY-OF-LIFE; DOUBLE-STRAND BREAKS; COMBINED PENTOXIFYLLINE; ORAL COMPLICATIONS; INDUCED TRISMUS; LATE TOXICITY; ATM PROTEIN; THERAPY; RADIOTHERAPY; RADIOSENSITIVITY;
D O I：
10.1177/11795549211036898
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Radiotherapy-related fibrosis remains one of the most challenging treatment related side effects encountered by patients with head and neck cancer. Several established and ongoing novel therapies have been studied with paucity of data in how to best treat these patients. This review aims to provide researchers and health care providers with a comprehensive review on the presentation, etiology, and therapeutic options for this serious condition.
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页数：7
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