Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach

被引：46

作者：

Ladame, S ^{[1
]}

Whitney, AM ^{[1
]}

Balasubramanian, S ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 35期

基金：

英国生物技术与生命科学研究理事会;

关键词：

combinatorial chemistry; DNA recognition; DNA structures; nucleic acids; template synthesis;

D O I：

10.1002/anie.200501450

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Reversible disulfide chemistry is used to identify ligands that stabilize either duplex or quadruplex DNA secondary structures from a dynamic combinatorial library of polyamide building blocks (example structure shown). Double-stranded DNA induces a larger amplification than quadruplex DNA, in accordance with the selectivity of the ligands for each DNA target. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5736 / 5739

页数：4