Anti-HIV properties of cationic fullerene derivatives

被引：115

作者：

Marchesan, S

Da Ros, T

Spalluto, G

Balzarini, J

Prato, M

机构：

[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy

[2] Katholieke Univ Leuven, Rega Inst Med Res, Lab Virol & Chemotherapy, B-3000 Louvain, Belgium

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 15期

关键词：

fullerene; fulleropyrrolidine; bis-adducts; anti-HIV activity;

D O I：

10.1016/j.bmcl.2005.05.069

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of regioisomeric bis-fulleropyrrolidines bearing two ammonium groups have been synthesized and their activities against HIV-1 and HIV-2 have been evaluated. Two trans isomers have been endowed with interesting antiviral properties, confirming the importance of the relative positions of the substituent on the C-60 cage. In addition, reduced amphiphilicity of molecules to other compounds previously reported decreases their cytotoxicity in CEM cell cultures. None of the compounds showed any inhibitory activity against a variety of DNA and RNA viruses other than HIV. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3615 / 3618

页数：4

共 28 条

[1] TREATMENT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)-INFECTED CELLS WITH COMBINATIONS OF HIV-1-SPECIFIC INHIBITORS RESULTS IN A DIFFERENT RESISTANCE PATTERN THAN DOES TREATMENT WITH SINGLE-DRUG THERAPY [J].