Neonatal Adenovirus Infection Complicated by Hemophagocytic Lymphohistiocytosis Syndrome

被引：25

作者：

Censoplano, Nina ^{[4
]}

Gorga, Stephen ^{[1
]}

Waldeck, Kate ^{[1
]}

Stillwell, Terri ^{[2
]}

Rabah-Hammad, Raja ^{[3
]}

Flori, Heidi ^{[1
]}

机构：

[1] Univ Michigan, CS Mott Childrens Hosp, Sch Med, Div Crit Care Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, CS Mott Childrens Hosp, Sch Med, Div Infect Dis, Ann Arbor, MI 48109 USA

[3] Univ Michigan, CS Mott Childrens Hosp, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[4] Univ Colorado Anschutz Med Campus, Childrens Hosp Colorado, Div Cardiol, Aurora, CO USA

来源：

PEDIATRICS | 2018年 / 141卷

关键词：

KAWASAKI-DISEASE; PNEUMONIA;

D O I：

10.1542/peds.2017-2061

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Two infants with disseminated adenoviral infections are described. Both these infants had a similar clinical course and were also diagnosed with secondary hemophagocytic lymphohistiocytosis (HLH). Previous reports of immunocompromised adults with adenovirus-associated HLH are in the literature; however, this is the first report that we are aware of with this pathology occurring in infants. These cases are used to demonstrate the importance of thinking about HLH in patients who are diagnosed with adenovirus and exhibit prolonged fevers that are unresponsive to antimicrobial agents with hepatosplenomegaly and cytopenias.

引用

页码：S475 / S480

页数：6

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