Chalcone synthesis, properties and medicinal applications: a review

被引：242

作者：

Rammohan, Aluru ^{[1
,2
]}

Reddy, Julakanti Satyanarayana ^{[3
]}

Sravya, Gundala ^{[1
]}

Rao, Chittluri Narasimha ^{[2
]}

Zyryanov, Grigory V. ^{[1
,4
]}

机构：

[1] Ural Fed Univ, Dept Organ & Biomol Chem, 19 Mira, Ekaterinburg 620002, Russia

[2] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

[3] Natl Hlth Res Inst, 37 Keyan Rd, Zhunan 35053, Miaoli County, Taiwan

[4] Russian Acad Sci, I Ya Postovskiy Inst Organ Synth, Ural Div, 22 S Kovalevskoy St, Ekaterinburg, Russia

来源：

ENVIRONMENTAL CHEMISTRY LETTERS | 2020年 / 18卷 / 02期

关键词：

Antidiabetic activity; Chalcones; Chemopreventors; Claisen-Schmidt condensation; Fluorescent material; Witting reaction; IN-VITRO; GLYCYRRHIZA-INFLATA; BIOLOGICAL EVALUATION; ISOPRENYL FLAVONOIDS; BETA-HYDROXYCHALCONE; ANTIOXIDANT ACTIVITY; LICOCHALCONE-A; SOLVENT-FREE; DERIVATIVES; CONSTITUENTS;

D O I：

10.1007/s10311-019-00959-w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chalcone is an aromatic ketone that forms the central core of many important biological compounds, which are known as chalcones. Chalcones are the biogenetic precursors of flavonoids and isoflavonoids, which are abundant in plants. Chalcones are active lead molecules in medicinal chemistry for the discovery of new drugs. Here, we review properties, biosynthesis and structural diversity of natural chalcones. Then, we present the synthesis of chalcones and their biological activities with focus on structure-activity relationships. Pharmaceutically important and patented chalcones are also discussed.

引用

页码：433 / 458

页数：26

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