Chalcone synthesis, properties and medicinal applications: a review

被引：213

作者：

Rammohan, Aluru ^{[1
,2
]}

Reddy, Julakanti Satyanarayana ^{[3
]}

Sravya, Gundala ^{[1
]}

Rao, Chittluri Narasimha ^{[2
]}

Zyryanov, Grigory V. ^{[1
,4
]}

机构：

[1] Ural Fed Univ, Dept Organ & Biomol Chem, 19 Mira, Ekaterinburg 620002, Russia

[2] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

[3] Natl Hlth Res Inst, 37 Keyan Rd, Zhunan 35053, Miaoli County, Taiwan

[4] Russian Acad Sci, I Ya Postovskiy Inst Organ Synth, Ural Div, 22 S Kovalevskoy St, Ekaterinburg, Russia

来源：

ENVIRONMENTAL CHEMISTRY LETTERS | 2020年 / 18卷 / 02期

关键词：

Antidiabetic activity; Chalcones; Chemopreventors; Claisen-Schmidt condensation; Fluorescent material; Witting reaction; IN-VITRO; GLYCYRRHIZA-INFLATA; BIOLOGICAL EVALUATION; ISOPRENYL FLAVONOIDS; BETA-HYDROXYCHALCONE; ANTIOXIDANT ACTIVITY; LICOCHALCONE-A; SOLVENT-FREE; DERIVATIVES; CONSTITUENTS;

D O I：

10.1007/s10311-019-00959-w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chalcone is an aromatic ketone that forms the central core of many important biological compounds, which are known as chalcones. Chalcones are the biogenetic precursors of flavonoids and isoflavonoids, which are abundant in plants. Chalcones are active lead molecules in medicinal chemistry for the discovery of new drugs. Here, we review properties, biosynthesis and structural diversity of natural chalcones. Then, we present the synthesis of chalcones and their biological activities with focus on structure-activity relationships. Pharmaceutically important and patented chalcones are also discussed.

引用

页码：433 / 458

页数：26

共 50 条

[1] Chalcone synthesis, properties and medicinal applications: a review
Aluru Rammohan
Julakanti Satyanarayana Reddy
Gundala Sravya
Chittluri Narasimha Rao
Grigory V. Zyryanov
Environmental Chemistry Letters, 2020, 18 : 433 - 458
[2] Advances in synthesis, medicinal properties and biomedical applications of pyridine derivatives: A comprehensive review
Sahu, Duryodhan
Sreekanth, P. S. Rama
Behera, Prasanta Kumar
Pradhan, Manoj Kumar
Patnaik, Amit
Salunkhe, Sachin
Cep, Robert
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS, 2024, 12
[3] Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry
Rajendran, Gayathri
Bhanu, Deepu
Aruchamy, Baladhandapani
Ramani, Prasanna
Pandurangan, Nanjan
Bobba, Kondapa Naidu
Oh, Eun Jung
Chung, Ho Yun
Gangadaran, Prakash
Ahn, Byeong-Cheol
PHARMACEUTICALS, 2022, 15 (10)
[4] Significance of Chalcone Scaffolds in Medicinal Chemistry
Mazumder, Rishav
Ichudaule, Ashmita
Ghosh, Ashmita
Deb, Subrata
Ghosh, Rajat
TOPICS IN CURRENT CHEMISTRY, 2024, 382 (03)
[5] Recent Progress in Environmentally-Friendly Methods for Chalcone Synthesis
Makwana, Jeky C.
Dabhi, Ranjitsinh C.
Shrivastav, Pranav S.
Maru, Jayesh J.
LETTERS IN ORGANIC CHEMISTRY, 2024, 21 (01) : 29 - 39
[6] Chalcone Scaffolds as Anticancer Drugs: A Review on Molecular Insight in Action of Mechanisms and Anticancer Properties
Shukla, Shefali
Sood, Anantpreet K.
Goyal, Kartika
Singh, Ambika
Sharma, Vaidehi
Guliya, Neha
Gulati, Shikha
Kumar, Sanjay
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2021, 21 (13) : 1650 - 1670
[7] Exploring Synthesis and Medicinal Applications of Andrographolide Derivatives: A Review
Qadir, Tanzeela
Shaikh, Shoaib
Kanth, Saadat A.
Singh, Jyotika
Baby, Maria
Sharma, Praveen Kumar
CURRENT ORGANIC CHEMISTRY, 2024, 28 (09) : 686 - 699
[8] A REVIEW ON SYNTHESIS OF CHALCONE DERIVATIVES USING NON- CONVENTIONAL METHODS.
Magdalena, Alvarez-Ramirez
Lauro, Figueroa-Valverde
Marcela, Rosas-Nexticapa
Maria, Mateu-Armad
Francisco, Diaz-Cedillo
HETEROCYCLIC LETTERS, 2023, 13 (01): : 217 - 227
[9] Synthesis and anticancer activity of chalcone analogues with sulfonyl groups
Muskinja, Jovana M.
Burmudzija, Adrijana Z.
Baskic, Dejan D.
Popovic, Suzana L.
Todorovic, Danijela V.
Zaric, Milan M.
Ratkovic, Zoran R.
MEDICINAL CHEMISTRY RESEARCH, 2019, 28 (03) : 279 - 291
[10] Synthesis and Biological Evaluation of Chalcone Derivatives (Mini Review)
Bukhari, Syed Nasir Abbas
Jasamai, Malina
Jantan, Ibrahim
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2012, 12 (13) : 1394 - 1403

← 1 2 3 4 5 →