Glucocorticoid-Induced Bone Disease

被引：488

作者：

Weinstein, Robert S. ^{[1
,2
]}

机构：

[1] Univ Arkansas Med Sci, Div Endocrinol & Metab, Ctr Osteoporosis & Metab Bone Dis, Dept Internal Med, Little Rock, AR 72205 USA

[2] Univ Arkansas Med Sci, Cent Arkansas Vet Healthcare Syst, Little Rock, AR 72205 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2011年 / 365卷 / 01期

关键词：

INDUCED OSTEOPOROSIS; POSTMENOPAUSAL WOMEN; VERTEBRAL FRACTURE; MINERAL DENSITY; DOUBLE-BLIND; ALENDRONATE; PREVENTION; APOPTOSIS; OSTEOCYTES; BISPHOSPHONATES;

D O I：

10.1056/NEJMcp1012926

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 55-year-old woman with severe, persistent asthma requiring glucocorticoid therapy for the past 3 months presents for care. Her medications include albuterol, inhaled fluticasone with salmeterol, montelukast, and prednisone (at a dose of 10 mg per day). In the past, she received several intermittent courses of prednisone at a dose of 15 mg or more per day. Her weight is 45.5 kg (100 lb), and her height 157.5 cm (62 in.); the body-mass index (the weight in kilograms divided by the square of the height in meters) is 18. Scattered wheezing is heard during expiration. Findings on vertebral percussion and rib-cage compression are unremarkable. How should her case be evaluated and managed to minimize the risk of fractures?

引用

页码：62 / 70

页数：9

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