Facile assembly of fused benzo[4,5]furo heterocycles

被引：85

作者：

Liu, Jing ^{[1
]}

Fitzgerald, Anne E. ^{[1
]}

Mani, Neelakandha S. ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, San Diego, CA 92121 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 07期

关键词：

D O I：

10.1021/jo8000595

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise synthesis of fused benzo[4,5]furo heterocycles 18 has been developed. Chemo/regioselective Suzuki coupling between 1,2-dihaloarene 17 and alpha-hydroxyphenylboronic acid or ester 20 gives biaryl phenol 19, which then undergoes copper(I) thiophene-2-carboxylate (CuTC)-mediated intramolecular cyclization to afford 18 in good overall yield. This method has broad substrate scope and allows facile assembly of a wide variety of benzo[4,5]furo heterocycles.

引用

页码：2951 / 2954

页数：4

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