DNA Nanotweezers for Biosensing Applications: Recent Advances and Future Prospects

被引：21

作者：

Liu, Shanshan ^{[1
]}

Xiang, Kaikai ^{[1
]}

Wang, Chunyan ^{[1
]}

Zhang, Yutian ^{[1
]}

Fan, Gao-Chao ^{[2
]}

Wang, Wenjing ^{[1
,3
]}

Han, Heyou ^{[1
]}

机构：

[1] Huazhong Agr Univ, Coll Sci, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China

[2] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Shandong Key Lab Biochem Anal, Qingdao 266042, Shandong, Peoples R China

[3] Hubei Univ, Coll Chem & Chem Engn, Key Lab Synth & Applicat Organ Funct Mol, Minist Educ, Wuhan 430062, Peoples R China

来源：

ACS SENSORS | 2022年 / 7卷 / 01期

基金：

中国国家自然科学基金;

关键词：

DNA nanotweezers; biosensing; toxin; metal ions; nucleic acids; logic gate; DNA nanotechnology; bio-imaging; NANO-TWEEZER TECHNIQUE; PEROXIDASE-ACTIVITY; ENZYME CASCADES; MESSENGER-RNA; URANIUM; NANOSTRUCTURES; COMPUTATION; NANOMACHINE; MICRORNA; MOLECULE;

D O I：

10.1021/acssensors.1c01647

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA nanotweezers (DTs) are reversible DNA nanodevices that can optionally switch between opened and closed states. Due to their excellent flexibility and high programmability, they have been recognized as a promising platform for constructing a diversity of biosensors and logic gates, as well as a versatile tool for molecular biology studies. In this review, we provide an overview of biosensing applications using DTs. First, the design and working principle of DTs are introduced. Next, the signal producing principles of DTs are summarized. Furthermore, biosensing applications of DTs for varying targets and purposes, both in buffers and complex biological environments, are highlighted. Finally, we provide potential opportunities and challenges for the further development of DTs.

引用

页码：3 / 20

页数：18

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