Catalytic Oxidative Carbonylation of Amino Moieties to Ureas, Oxamides, 2-Oxazolidinones, and Benzoxazolones

被引：55

作者：

Mancuso, Raffaella ^{[1
,2
]}

Raut, Dnyaneshwar S. ^{[1
]}

Della Ca', Nicola ^{[3
,4
]}

Fini, Francesco ^{[5
]}

Carfagna, Carla ^{[6
]}

Gabriele, Bartolo ^{[1
]}

机构：

[1] Univ Calabria, Dipartimento Chim & Tecnol Chim, I-87036 Arcavacata Di Rende, CS, Italy

[2] Univ Calabria, Dipartimento Ingn Meccan Energet & Gestionale, I-87036 Arcavacata Di Rende, CS, Italy

[3] Univ Parma, Dipartimento Chim, I-43124 Parma, Italy

[4] Univ Parma, CIRCC, I-43124 Parma, Italy

[5] Univ Urbino, Dipartimento Sci Biomol, I-61029 Urbino, PU, Italy

[6] Univ Bologna, Dipartimento Chim Ind Toso Montanari, I-40136 Bologna, Italy

来源：

CHEMSUSCHEM | 2015年 / 8卷 / 13期

关键词：

amines; amino alcohols; carbonylation; ionic liquids; palladium; OXAZOLIDINONE ANTIBACTERIAL AGENTS; IONIC LIQUIDS; BIOLOGICAL-ACTIVITY; ORGANIC-SYNTHESIS; REACTION MEDIA; IN-VIVO; DERIVATIVES; INHIBITORS; EFFICIENT; DESIGN;

D O I：

10.1002/cssc.201500343

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct syntheses of ureas, oxamides, 2-oxazolidinones, and benzoxazolones by the oxidative carbonylation of amines, -amino alcohols, and 2-aminophenols allows us to obtain high value added molecules, which have a large number of important applications in several fields, from very simple building blocks. We have found that it is possible to perform these transformations using the PdI2/KI catalytic system in an ionic liquid, such as 1-butyl-3-methylimidazolium tetrafluoroborate, as the solvent, the solvent/catalyst system can be recycled several times with only a slight loss of activity, and the product can be recovered easily by crystallization.

引用

页码：2204 / 2211

页数：8