The copper-zinc superoxide dismutase activity in selected diseases

被引：72
作者：
Lewandowski, Lukasz [1 ]
Kepinska, Marta [1 ]
Milnerowicz, Halina [1 ]
机构：
[1] Wroclaw Med Univ, Div Lab Diagnost, Fac Pharm, Dept Biomed & Environm Anal, Wroclaw, Poland
来源：
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 2019年 / 49卷 / 01期
关键词：
copper-zinc superoxide dismutase; enzyme activity; single-nucleotide polymorphism; INCREASED OXIDATIVE STRESS; DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE; GENETIC POLYMORPHISMS; ANTIOXIDANT DEFENSES; LIPID-PEROXIDATION; SKELETAL-MUSCLE; RENAL INJURY; EXPRESSION; COPD;
D O I：
10.1111/eci.13036
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Copper-zinc superoxide dismutase (Cu,Zn-SOD) plays a protective role in various types of tissue protecting them from oxidative damage. Alterations in Cu,Zn-SOD (SOD1 and SOD3) activity and its expression have been observed in pathological occurrences most prevalent in modern society, including inflammatory bowel disease, obesity and its implications-diabetes and hypertension, and chronic obstructive pulmonary disease. Moreover, several SOD1 and SOD3 gene polymorphisms have been associated with the risk of developing a particular type of disease, or its exacerbation. This article features recent observations in this topic, aiming to show the importance of proper gene sequence and activity of Cu,Zn-SOD in the aforementioned diseases.
引用
收藏
页数：10
相关论文
共 77 条
  • [1] Impact of the components of metabolic syndrome on oxidative stress and enzymatic antioxidant activity in essential hypertension
    Abdilla, N.
    Tormo, M. C.
    Fabia, M. J.
    Chaves, F. J.
    Saez, G.
    Redon, J.
    [J]. JOURNAL OF HUMAN HYPERTENSION, 2007, 21 (01) : 68 - 75
  • [2] Age-related change of plasma extracellular-superoxide dismutase
    Adachi, T
    Wang, J
    Wang, XL
    [J]. CLINICA CHIMICA ACTA, 2000, 290 (02) : 169 - 178
  • [3] Impaired enzymatic antioxidant defense in erythrocytes of women with general and abdominal obesity
    Amirkhizi, Farshad
    Siassi, Fereydoun
    Djalali, Mahmoud
    Shahraki, Soudabeh Hamedi
    [J]. OBESITY RESEARCH & CLINICAL PRACTICE, 2014, 8 (01) : E26 - E34
  • [4] Beltowski J, 2000, J PHYSIOL PHARMACOL, V51, P883
  • [5] The pathobiology of diabetic complications - A unifying mechanism
    Brownlee, M
    [J]. DIABETES, 2005, 54 (06) : 1615 - 1625
  • [6] DEPLETED MUCOSAL ANTIOXIDANT DEFENSES IN INFLAMMATORY BOWEL-DISEASE
    BUFFINTON, GD
    DOE, WF
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 1995, 19 (06) : 911 - 918
  • [7] Enhanced Skeletal Muscle Expression of Extracellular Superoxide Dismutase Mitigates Streptozotocin-Induced Diabetic Cardiomyopathy by Reducing Oxidative Stress and Aberrant Cell Signaling
    Call, Jarrod A.
    Chain, Kristopher H.
    Martin, Kyle S.
    Lira, Vitor A.
    Okutsu, Mitsuharu
    Zhang, Mei
    Yan, Zhen
    [J]. CIRCULATION-HEART FAILURE, 2015, 8 (01) : 188 - 197
  • [8] The implication of obesity on total antioxidant capacity in apparently healthy men and women: The ATTICA study
    Chrysohoou, Christina
    Panagiotakos, Demosthenes B.
    Pitsavos, Christos
    Skoumas, Ioannis
    Papademetriou, Lambros
    Economou, Manolis
    Stefanadis, Christodoulos
    [J]. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2007, 17 (08) : 590 - 597
  • [9] Overexpression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice
    Craven, PA
    Melhem, MF
    Phillips, SL
    DeRubertis, FR
    [J]. DIABETES, 2001, 50 (09) : 2114 - 2125
  • [10] Overexpression of superoxide dismutase 3 gene blocks high-fat diet-induced obesity, fatty liver and insulin resistance
    Cui, R.
    Gao, M.
    Qu, S.
    Liu, D.
    [J]. GENE THERAPY, 2014, 21 (09) : 840 - 848
12345678