A new convenient synthesis of 3-carhoxycephems starting from 7-aminocephalosporanic acid (7-ACA)

被引：0
|
作者：
Keltjens, R
Vadivel, SK
de Vroom, E
Klunder, AJH
Zwanenburg, B
机构：
[1] Univ Nijmegen, NSR Inst Mol Struct Design & Synth, Dept Organ Chem, NL-6525 ED Nijmegen, Netherlands
[2] DSM Anti Infect, NL-2600 MA Delft, Netherlands
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 2001卷 / 13期
关键词：
antibiotics; oxidations; lactams; carboxylic acids;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New convenient syntheses of 3-carboxycephems starting from 7-ACA are reported. All three possible cephem derivatives with respect to the position of the double bond in the six-membered ring and oxidation state of the sulfur atom have been synthesized in high overall yield.
引用
收藏
页码：2529 / 2534
页数：6
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