Immunoactive ionic liquids based on 2-hydroxyethylamines and 1-R-indol-3-ylsulfanylacetic acids. Crystal and molecular structure of immunodepressant tris-(2-hydroxyethyl)ammonium indol-3-ylsulfanylacetate

被引：12

作者：

Mirskova, Anna N. ^{[2
]}

Adamovich, Sergey N. ^{[2
]}

Mirskov, Rudolf G. ^{[2
]}

Kolesnikova, Olga P. ^{[3
]}

Schilde, Uwe ^{[1
]}

机构：

[1] Univ Potsdam, Inst Chem, D-14476 Golm, Germany

[2] Russian Acad Sci, Siberian Branch, AE Favorsky Irkutsk Inst Chem, Irkutsk 664033, Russia

[3] Russian Acad Med Sci, Siberian Branch, Res Inst Clin Immunol, Novosibirsk 630099, Russia

来源：

OPEN CHEMISTRY | 2015年 / 13卷 / 01期

关键词：

Protic 2-hydroxyethylammonium ionic liquids; 2-Hydroxyethylammonium; 1-R-indol-3-ylsulfanylacetates; Crystal and molecular structure; Immunoactive properties; ACTIVE PHARMACEUTICAL INGREDIENTS; SALTS;

D O I：

10.1515/chem-2015-0018

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Immunoactive ionic liquids (2-hydroxyethyl) ammonium 1-R-indol-3-ylsulfanyl-acetates HN+R1R2(CH2CH2OH)center dot O-(O)CCH2S-Ind-R-3-1(1-5), were synthesized by the reaction of (2-hydroxyethyl)amines with indol-3-ylsulfanylacetic- or 1-benzylindol-3-ylsulfanylacetic acid. 1: R-1 = R-2 = CH2CH2OH, R-3 = H; 2: R-1 =CH3, R-2=CH2CH2OH, R3 = H; 3: R-1 = R-2 = CH3, R-3 = H; 4: R-1 = R-2 = CH2CH2OH, R-3 = CH2C6H5; 5: R-1 = CH3; R-2 = CH2CH2OH; R-3 = CH2C6H5. The structure of each compound was elucidated by IR, NMR H-1, C-13, and N-15 techniques and their composition was confirmed by elemental analysis. The crystal structure of tris-(2-hydroxyethyl) ammonium indol-3-ylsulfanylacetate was investigated by X-ray diffraction analysis. Immunoactive properties of the title compounds were screened.

引用

页码：149 / 155

页数：7

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