Amino acid uptake in erythropoiesis

被引:6
作者
Nathan, David G. [1 ]
机构
[1] Harvard Univ, Boston Childrens Hosp, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA
关键词
KINETICS;
D O I
10.1126/scisignal.aab1203
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Erythroblasts produce huge amounts of hemoglobin, for which they must incorporate vast stores of iron and amino acids. In the 14 April issue of Science Signaling, Chung et al. describe the complex mechanism linking neutral amino acid uptake to hemoglobin production in these hungry cells.
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页数:2
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共 8 条
[1]   CELLULAR KINETICS AND IRON UTILIZATION IN BONE MARROW AS OBSERVED BY FE59 RADIOAUTOGRAPHY [J].
ALPEN, EL ;
CRANMORE, D .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1959, 77 (03) :753-765
[2]   The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability [J].
Chung, Jacky ;
Bauer, Daniel E. ;
Ghamari, Alireza ;
Nizzi, Christopher P. ;
Deck, Kathryn M. ;
Kingsley, Paul D. ;
Yien, Yvette Y. ;
Huston, Nicholas C. ;
Chen, Caiyong ;
Schultz, Iman J. ;
Dalton, Arthur J. ;
Wittig, Johannes G. ;
Palis, James ;
Orkin, Stuart H. ;
Lodish, Harvey F. ;
Eisenstein, Richard S. ;
Cantor, Alan B. ;
Paw, Barry H. .
SCIENCE SIGNALING, 2015, 8 (372)
[3]   Non-heme Iron as Ferrous Sulfate Does Not Interact with Heme Iron Absorption in Humans [J].
Gaitan, Diego ;
Olivares, Manuel ;
Loennerdal, Bo ;
Brito, Alex ;
Pizarro, Fernando .
BIOLOGICAL TRACE ELEMENT RESEARCH, 2012, 150 (1-3) :68-73
[4]   KINETICS OF IRON ABSORPTION IN MICE [J].
GITLIN, D ;
CRUCHAUD, A .
JOURNAL OF CLINICAL INVESTIGATION, 1962, 41 (02) :344-&
[5]   L-leucine alleviates Diamond-Blackfan anemia [J].
Kamimae-Lanning, Ashley N. ;
Kurre, Peter .
BLOOD, 2012, 120 (11) :2157-2158
[6]   SINGLE CELL ORIGIN OF MULTILINEAGE COLONIES IN CULTURE - EVIDENCE THAT DIFFERENTIATION OF MULTIPOTENT PROGENITORS AND RESTRICTION OF PROLIFERATIVE POTENTIAL OF MONOPOTENT PROGENITORS ARE STOCHASTIC-PROCESSES [J].
LEARY, AG ;
OGAWA, M ;
STRAUSS, LC ;
CIVIN, CI .
JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (06) :2193-2197
[7]   HUMAN ERYTHROID BURST-FORMING UNIT - T-CELL REQUIREMENT FOR PROLIFERATION INVITRO [J].
NATHAN, DG ;
CHESS, L ;
HILLMAN, DG ;
CLARKE, B ;
BREARD, J ;
MERLER, E ;
HOUSMAN, DE .
JOURNAL OF EXPERIMENTAL MEDICINE, 1978, 147 (02) :324-339
[8]   Hematopoiesis: An evolving paradigm for stem cell biology [J].
Orkin, Stuart H. ;
Zon, Leonard I. .
CELL, 2008, 132 (04) :631-644