Targeting NF-κB and induction of apoptosis by novel NF-κB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) in Burkitt lymphoma cells

被引：15
作者：
Kimura, Noriko
Miyakawa, Yoshitaka [1 ]
Kohmura, Kanoko
Umezawa, Kazuo
Ikeda, Yasuo
Kizaki, Masahiro
机构：
[1] Keio Univ, Sch Med, Dept Internal Med, Div Hematol, Tokyo 1608582, Japan
[2] Keio Univ, Fac Sci & Technol, Dept Appl Chem, Kanagawa, Japan
来源：
LEUKEMIA RESEARCH | 2007年 / 31卷 / 11期
关键词：
NF-kappa B; Burkitt lymphoma; apoptosis; caspase-3; IAP;
D O I：
10.1016/j.leukres.2007.02.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A new NF-kappa B inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), inhibited proliferation and induced apoptosis in human Burkitt lymphoma, HS-Sultan and Daudi cell lines. The activation of caspase-3 and the cleavage of caspase substrate PARP were observed after treatment with DHMEQ. The induction of apoptosis by DHMEQ was prevented by the pretreatment of Burkitt lymphoma cells with pan-caspase inhibitor, z-VAD-FMK. The expression of anti-apoptotic factors such as IAP-1 and XIAP was suppressed by DHMEQ. Phosphorylation of ERK and INK was induced by DHMEQ. In conclusion, these results demonstrate that NF-kappa B might be an ideal target to develop for new anti-cancer drugs for Burkitt lymphoma. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1529 / 1535
页数：7
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