A Multifunctional Probe with Aggregation-Induced Emission Characteristics for Selective Fluorescence Imaging and Photodynamic Killing of Bacteria Over Mammalian Cells

被引：91
作者：
Gao, Meng [1 ]
Hu, Qinglian [2 ]
Feng, Guangxue [3 ]
Tomczak, Nikodem [1 ,4 ]
Liu, Rongrong [1 ]
Xing, Bengang [5 ]
Tang, Ben Zhong [6 ]
Liu, Bin [1 ,2 ]
机构：
[1] ASTAR, Inst Mat Res Engn, Singapore 117602, Singapore
[2] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117585, Singapore
[3] Hong Kong Univ Sci & Technol, Dept Chem, Div Biomed Engn, Kowloon, Hong Kong, Peoples R China
[4] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
[5] Nanyang Technol Univ, Div Chem & Biol Chem, Singapore 637371, Singapore
[6] S China Univ Technol, SCUT HKUST Joint Res Lab, Guangdong Innovat Res Team, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Guangdong, Peoples R China
来源：
ADVANCED HEALTHCARE MATERIALS | 2015年 / 4卷 / 05期
基金：
新加坡国家研究基金会;
关键词：
INTRAMOLECULAR PROTON-TRANSFER; LIGHT-UP PROBE; PHOTOPHYSICAL PROPERTIES; STATE; INACTIVATION; INFECTION; CHEMOTHERAPY; RECOGNITION; EFFICIENCY; PORPHYRINS;
D O I：
10.1002/adhm.201400654
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A multifunctional probe aggregation-induced emission-Zinc(II)-dipicolylamine (AIE-ZnDPA) is developed for selective targeting, fluorescence imaging, and photodynamic killing of both Gram-positive and Gram-negative bacteria over mammalian cells. The probe has significant advantages in simple probe design, enhanced fluorescence upon bacteria binding, excellent photostability, and broad-spectrum antibacterial activity with almost no harm to mammalian cells. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：659 / 663
页数：5
相关论文
共 55 条
[1]   Indirect detection of photosensitizer ex vivo [J].
Bourré, L ;
Thibaut, S ;
Briffaud, A ;
Rousset, N ;
Eléouet, S ;
Lajat, Y ;
Patrice, T .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2002, 67 (01) :23-31
[2]   Photodynamic Antifungal Chemotherapy [J].
Calzavara-Pinton, Piergiacomo ;
Rossi, M. Teresa ;
Sala, Raffaella ;
Venturini, Marina .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2012, 88 (03) :512-522
[3]   Light and dark biocidal activity of cationic poly(arylene ethynylene) conjugated polyelectrolytes [J].
Corbitt, Thomas S. ;
Ding, Liping ;
Ji, Eunkyung ;
Ista, Linnea K. ;
Ogawa, Katsu ;
Lopez, Gabriel P. ;
Schanze, Kirk S. ;
Whitten, David G. .
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2009, 8 (07) :998-1005
[4]   Bioprobes Based on AIE Fluorogens [J].
Ding, Dan ;
Li, Kai ;
Liu, Bin ;
Tang, Ben Zhong .
ACCOUNTS OF CHEMICAL RESEARCH, 2013, 46 (11) :2441-2453
[5]   Zinc(II) coordination complexes as membrane-active fluorescent probes and antibiotics [J].
DiVittorio, Kristy M. ;
Leevy, W. Matthew ;
O'Neil, Edward J. ;
Johnson, James R. ;
Vakulenko, Sergei ;
Morris, Joshua D. ;
Rosek, Kristine D. ;
Serazin, Nathan ;
Hilkert, Sarah ;
Hurley, Scott ;
Marquez, Manuel ;
Smith, Bradley D. .
CHEMBIOCHEM, 2008, 9 (02) :286-293
[6]   Selective lethal photosensitization of methicillin-resistant Staphylococcus aureus using an IgG-tin(IV) chlorin e6 conjugate [J].
Embleton, ML ;
Nair, SP ;
Cookson, BD ;
Wilson, M .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 50 (06) :857-864
[7]   A fluorescent light-up probe with AIE characteristics for specific mitochondrial imaging to identify differentiating brown adipose cells [J].
Gao, Meng ;
Sim, Choon Kiat ;
Leung, Chris Wai Tung ;
Hu, Qinglian ;
Feng, Guangxue ;
Xu, Feng ;
Tang, Ben Zhong ;
Liu, Bin .
CHEMICAL COMMUNICATIONS, 2014, 50 (61) :8312-8315
[8]   A fluorescent light-up probe with "AIE plus ESIPT" characteristics for specific detection of lysosomal esterase [J].
Gao, Meng ;
Hu, Qinglian ;
Feng, Guangxue ;
Tang, Ben Zhong ;
Liu, Bin .
JOURNAL OF MATERIALS CHEMISTRY B, 2014, 2 (22) :3438-3442
[9]   Aggregation-induced emission [J].
Hong, Yuning ;
Lam, Jacky W. Y. ;
Tang, Ben Zhong .
CHEMICAL SOCIETY REVIEWS, 2011, 40 (11) :5361-5388
[10]   Targeted Bioimaging and Photodynamic Therapy of Cancer Cells with an Activatable Red Fluorescent Bioprobe [J].
Hu, Fang ;
Huang, Yanyan ;
Zhang, Guanxin ;
Zhao, Rui ;
Yang, Hua ;
Zhang, Deqing .
ANALYTICAL CHEMISTRY, 2014, 86 (15) :7987-7995
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