A Multifunctional Probe with Aggregation-Induced Emission Characteristics for Selective Fluorescence Imaging and Photodynamic Killing of Bacteria Over Mammalian Cells

被引：90

作者：

Gao, Meng ^{[1
]}

Hu, Qinglian ^{[2
]}

Feng, Guangxue ^{[3
]}

Tomczak, Nikodem ^{[1
,4
]}

Liu, Rongrong ^{[1
]}

Xing, Bengang ^{[5
]}

Tang, Ben Zhong ^{[6
]}

Liu, Bin ^{[1
,2
]}

机构：

[1] ASTAR, Inst Mat Res Engn, Singapore 117602, Singapore

[2] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117585, Singapore

[3] Hong Kong Univ Sci & Technol, Dept Chem, Div Biomed Engn, Kowloon, Hong Kong, Peoples R China

[4] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[5] Nanyang Technol Univ, Div Chem & Biol Chem, Singapore 637371, Singapore

[6] S China Univ Technol, SCUT HKUST Joint Res Lab, Guangdong Innovat Res Team, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Guangdong, Peoples R China

来源：

ADVANCED HEALTHCARE MATERIALS | 2015年 / 4卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

INTRAMOLECULAR PROTON-TRANSFER; LIGHT-UP PROBE; PHOTOPHYSICAL PROPERTIES; STATE; INACTIVATION; INFECTION; CHEMOTHERAPY; RECOGNITION; EFFICIENCY; PORPHYRINS;

D O I：

10.1002/adhm.201400654

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A multifunctional probe aggregation-induced emission-Zinc(II)-dipicolylamine (AIE-ZnDPA) is developed for selective targeting, fluorescence imaging, and photodynamic killing of both Gram-positive and Gram-negative bacteria over mammalian cells. The probe has significant advantages in simple probe design, enhanced fluorescence upon bacteria binding, excellent photostability, and broad-spectrum antibacterial activity with almost no harm to mammalian cells. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：659 / 663

页数：5

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