Unraveling the Complexity of Liver Disease One Cell at a Time

被引：3
作者：
Atif, Jawairia [1 ,2 ]
Thoeni, Cornelia [3 ]
Bader, Gary D. [4 ,5 ]
McGilvray, Ian D. [1 ]
MacParland, Sonya A. [1 ,2 ,3 ]
机构：
[1] Univ Hlth Network, Ajmera Transplant Ctr, Schwartz Reisman Liver Res Ctr, Toronto Gen Res Inst, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada
[2] Univ Toronto, Dept Immunol, Med Sci Bldg, Toronto, ON, Canada
[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[4] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada
[5] Univ Toronto, Donnelly Ctr, Toronto, ON, Canada
来源：
SEMINARS IN LIVER DISEASE | 2022年 / 42卷 / 03期
关键词：
single-cell transcriptomics; liver cancer; hepatitis; GENOME-WIDE ASSOCIATION; INFILTRATING T-CELLS; SINGLE-CELL; HEPATOCELLULAR-CARCINOMA; INTERCELLULAR CROSSTALK; INTEGRATED ANALYSIS; ULCERATIVE-COLITIS; ENDOTHELIAL-CELLS; SOLID TUMORS; RISK LOCI;
D O I：
10.1055/s-0042-1755272
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The human liver is a complex organ made up of multiple specialized cell types that carry out key physiological functions. An incomplete understanding of liver biology limits our ability to develop therapeutics to prevent chronic liver diseases, liver cancers, and death as a result of organ failure. Recently, single-cell modalities have expanded our understanding of the cellular phenotypic heterogeneity and intercellular cross-talk in liver health and disease. This review summarizes these findings and looks forward to highlighting new avenues for the application of single-cell genomics to unravel unknown pathogenic pathways and disease mechanisms for the development of new therapeutics targeting liver pathology. As these technologies mature, their integration into clinical data analysis will aid in patient stratification and in developing treatment plans for patients suffering from liver disease.
引用
收藏
页码：250 / 270
页数：21
相关论文
共 156 条
  • [1] Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation
    Abdel-Hakeem, Mohamed S.
    Manne, Sasikanth
    Beltra, Jean-Christophe
    Stelekati, Erietta
    Chen, Zeyu
    Nzingha, Kito
    Ali, Mohammed-Alkhatim
    Johnson, John L.
    Giles, Josephine R.
    Mathew, Divij
    Greenplate, Allison R.
    Vahedi, Golnaz
    Wherry, E. John
    [J]. NATURE IMMUNOLOGY, 2021, 22 (08) : 1008 - +
  • [2] Effect of FGFR2 alterations on survival in patients receiving systemic chemotherapy for intrahepatic cholangiocarcinoma.
    Abou-Alfa, Ghassan K.
    Bibeau, Kristen
    Schultz, Nikolaus
    Yaqubie, Amin
    Millang, Brittanie M.
    Ren Haobo
    Feliz, Luis
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (03)
  • [3] Ivosidenib in IDH1-mutant, chemotherapy-refractory Croatia& cholangiocarcinoma (ClarlDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study
    Abou-Alfa, Ghassan K.
    Macarulla, Teresa
    Javle, Milind M.
    Kelley, Robin K.
    Lubner, Sam J.
    Adeva, Jorge
    Cleary, James M.
    Catenacci, Daniel V.
    Borad, Mitesh J.
    Bridgewater, John
    Harris, William P.
    Murphy, Adrian G.
    Oh, Do-Youn
    Whisenant, Jonathan
    Lowery, Maeve A.
    Goyal, Lipika
    Shroff, Rachna T.
    El-Khoueiry, Anthony B.
    Fan, Bin
    Wu, Bin
    Chamberlain, Christina X.
    Jiang, Liewen
    Gliser, Camelia
    Pandya, Shuchi S.
    Valle, Juan W.
    Zhu, Andrew X.
    [J]. LANCET ONCOLOGY, 2020, 21 (06) : 796 - 807
  • [4] Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis
    Aegidius, Helene M.
    Veidal, Sanne S.
    Feigh, Michael
    Hallenborg, Philip
    Puglia, Michele
    Pers, Tune H.
    Vrang, Niels
    Jelsing, Jacob
    Kornum, Birgitte R.
    Blagoev, Blagoy
    Rigbolt, Kristoffer T. G.
    [J]. SCIENTIFIC REPORTS, 2020, 10 (01)
  • [5] A human liver cell atlas reveals heterogeneity and epithelial progenitors
    Aizarani, Nadim
    Saviano, Antonio
    Sagar
    Mailly, Laurent
    Durand, Sarah
    Herman, Josip S.
    Pessaux, Patrick
    Baumert, Thomas F.
    Gruen, Dominic
    [J]. NATURE, 2019, 572 (7768) : 199 - 204
  • [6] Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer
    Ali, H. Raza
    Jackson, Hartland W.
    Zanotelli, Vito R. T.
    Danenberg, Esther
    Fischer, Jana R.
    Bardwell, Helen
    Provenzano, Elena
    Rueda, Oscar M.
    Chin, Suet-Feung
    Aparicio, Samuel
    Caldas, Carlos
    Bodenmiller, Bernd
    [J]. NATURE CANCER, 2020, 1 (02) : 163 - +
  • [7] Single-Cell, Single-Nucleus, and Spatial RNA Sequencing of the Human Liver Identifies Cholangiocyte and Mesenchymal Heterogeneity
    Andrews, Tallulah S.
    Atif, Jawairia
    Liu, Jeff C.
    Perciani, Catia T.
    Ma, Xue-Zhong
    Thoeni, Cornelia
    Slyper, Michal
    Eraslan, Gokcen
    Segerstolpe, Asa
    Manuel, Justin
    Chung, Sai
    Winter, Erin
    Cirlan, Iulia
    Khuu, Nicholas
    Fischer, Sandra
    Rozenblatt-Rosen, Orit
    Regev, Aviv
    McGilvray, Ian D.
    Bader, Gary D.
    MacParland, Sonya A.
    [J]. HEPATOLOGY COMMUNICATIONS, 2022, 6 (04) : 821 - 840
  • [8] Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
    Aran, Dvir
    Looney, Agnieszka P.
    Liu, Leqian
    Wu, Esther
    Fong, Valerie
    Hsu, Austin
    Chak, Suzanna
    Naikawadi, Ram P.
    Wolters, Paul J.
    Abate, Adam R.
    Butte, Atul J.
    Bhattacharya, Mallar
    [J]. NATURE IMMUNOLOGY, 2019, 20 (02) : 163 - +
  • [9] Joint analysis of expression levels and histological images identifies genes associated with tissue morphology
    Ash, Jordan T.
    Darnell, Gregory
    Munro, Daniel
    Engelhardt, Barbara E.
    [J]. NATURE COMMUNICATIONS, 2021, 12 (01)
  • [10] Spatial sorting enables comprehensive characterization of liver zonation
    Ben-Moshe, Shani
    Shapira, Yonatan
    Moor, Andreas E.
    Manco, Rita
    Veg, Tamar
    Halpern, Keren Bahar
    Itzkovitz, Shalev
    [J]. NATURE METABOLISM, 2019, 1 (09) : 899 - 911
12345678910